The first example of anti-Diego(b) found in a Polish woman with the Di(a+b-) phenotype and haemolytic disease of the newborn not requiring treatment

All pregnant women with anti-Diegob (anti-Dib) described so far were non-Caucasians. We present the case of a Polish Di(a+b-) woman with anti-Dib, which did not bind complement, was immunoglobulin G3 (IgG3) alone and had very low functional activity. She delivered a Di(a+b+) infant with a positive d...

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Bibliographic Details
Published in:Transfusion medicine (Oxford, England) England), 2003-06, Vol.13 (3), p.161-163
Main Authors: Lenkiewicz, B, Zupańska, B
Format: Article
Language:English
Subjects:
Adult
Blood Group Antigens - immunology
Erythroblastosis, Fetal - etiology
European Continental Ancestry Group - ethnology
Family Health
Female
Humans
Infant, Newborn
Pedigree
Phenotype
Poland - ethnology
Pregnancy
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Summary:All pregnant women with anti-Diegob (anti-Dib) described so far were non-Caucasians. We present the case of a Polish Di(a+b-) woman with anti-Dib, which did not bind complement, was immunoglobulin G3 (IgG3) alone and had very low functional activity. She delivered a Di(a+b+) infant with a positive direct antiglobulin test and the antibody in his serum but very mild haemolytic disease. Both parents of the pregnant woman were Di(a+b+), so were all her three children. The whole family have been living in a small village in southeastern Poland for a long time. The rare Diego phenotypes, found now and previously in Poland, suggest gene admixture introduced as a result of Poland being invaded by Mongolian-background Tatars during the past centuries.
ISSN:0958-7578
DOI:10.1046/j.1365-3148.2003.00437.x