Does donor race still make a difference in deceased-donor African-American renal allograft recipients?

Abstract Background Prior studies have demonstrated that African-American (AA) donor kidneys are independently associated with an increased risk for graft loss. Methods We examined outcomes in comparable groups of AA deceased-donor (DD) kidney transplant patients receiving an AA donor (n = 35) versu...

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Bibliographic Details
Published in:The American journal of surgery 2010-03, Vol.199 (3), p.305-309
Main Authors: Brown, Kristian L., M.D, Doshi, Mona D., M.D, Singh, Atul, M.D, Mehta, Kalyani, M.D, Morawski, Katherina, R.N., B.S.N., C.N.N, Cincotta, Elizabeth, Pharm.D, West, Miguel S., M.D., F.A.C.S, Gruber, Scott A., M.D., Ph.D., M.B.A., F.A.C.S
Format: Article
Language:English
Subjects:
Adult
African American
African Americans
Blood & organ donations
Cytomegalovirus
Diabetes mellitus
Donor race
European Continental Ancestry Group
Female
Graft rejection
Graft Rejection - epidemiology
Graft Survival
Grafting
Humans
Immunosuppression
Incidence
Infections
Kidney Transplantation
Kidney transplants
Kidneys
Male
Middle Aged
Minority & ethnic groups
Nephropathy
Noncompliance
Patients
Recurrent infection
Rejection
Retrospective Studies
Risk Factors
Surgery
Survival
Tissue Donors
Transplants & implants
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Summary:Abstract Background Prior studies have demonstrated that African-American (AA) donor kidneys are independently associated with an increased risk for graft loss. Methods We examined outcomes in comparable groups of AA deceased-donor (DD) kidney transplant patients receiving an AA donor (n = 35) versus a Caucasian donor (C group; n = 150) organ. Results There were no differences between AA and C groups in patient survival, new-onset diabetes, or BK nephropathy. The AA group demonstrated a significantly higher 6-month and overall incidence of acute rejection (AR), increased cytomegalovirus (CMV) infection, and decreased graft survival. Recurrent or de novo focal segmental glomerulosclerosis (FSGS) accounted for a significantly higher fraction of graft losses in the AA versus C group. Conclusions AA DD renal allograft recipients have equivalent patient but decreased graft survival when transplanted with an AA versus C kidney using current immunosuppression. This may be the result of increased AR, CMV infection, and recurrence/development of FSGS.
ISSN:0002-9610
1879-1883
DOI:10.1016/j.amjsurg.2009.08.025