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Chronic Increase of Bone Turnover Markers After Biliopancreatic Diversion is Related to Secondary Hyperparathyroidism and Weight Loss. Relation with Bone Mineral Density

Background Biliopancreatic diversion (BPD) is the most effective bariatric procedure. Around 70% of these patients have secondary hyperparathyroidism (SH) in the long term as a consequence of calcium and vitamin D malabsorption. This work was aimed to study the influence of SH on bone turnover and i...

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Bibliographic Details
Published in:Obesity surgery 2010-04, Vol.20 (4), p.468-473
Main Authors: Balsa, José Antonio, Botella-Carretero, José I., Peromingo, Roberto, Caballero, Carmen, Muñoz-Malo, Teresa, Villafruela, Juan J., Arrieta, Francisco, Zamarrón, Isabel, Vázquez, Clotilde
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Language:English
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Summary:Background Biliopancreatic diversion (BPD) is the most effective bariatric procedure. Around 70% of these patients have secondary hyperparathyroidism (SH) in the long term as a consequence of calcium and vitamin D malabsorption. This work was aimed to study the influence of SH on bone turnover and its relationship with bone mineral density (BMD). Methods Bone turnover markers were determined in 63 BPD patients and 34 morbidly obese controls. In the BPD group, we also studied the influence of age, loss of weight, common channel length, PTH, vitamin D, and serum calcium on bone turnover as well as its relation with BMD. Results BPD patients showed significantly higher PTH, osteocalcin, and β-CTx levels than controls. In the multivariate regression analysis, only PTH ( β  = 0.42; P  = 0.0002), menopausal status ( β  = 0.31; P  = 0.007) and the percentage of lost BMI ( β  = −0.24; P  = 0.03) significantly predicted the osteocalcin level ( R 2  = 0.33; F  = 9.56; P  
ISSN:0960-8923
1708-0428
DOI:10.1007/s11695-009-0028-z