Utility of iodine and 7,7,8,8-tetracyanoquinodimethane for determination of terfenadine

Simple and sensitive spectrophotometric methods for the assay of terfenadine are described. The first is based on the reaction of terfenadine with iodine to give a molecular charge-transfer complex, the terfenadine acting as an n-electron donor and iodine as a σ-electron acceptor. The second depends...

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Bibliographic Details
Published in:Talanta (Oxford) 1988-03, Vol.35 (3), p.242-244
Main Authors: Abdel-Hamid, Mohamed E., Abuirjeie, Mustafa A.
Format: Article
Language:English
Subjects:
Analysis
Biological and medical sciences
General pharmacology
Medical sciences
Pharmacology. Drug treatments
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Summary:Simple and sensitive spectrophotometric methods for the assay of terfenadine are described. The first is based on the reaction of terfenadine with iodine to give a molecular charge-transfer complex, the terfenadine acting as an n-electron donor and iodine as a σ-electron acceptor. The second depends on the formation of a highly coloured stable radical anion between terfenadine and 7,7,8,8-tetracyanoquinodimethane (TCNQ) as a π-electron acceptor. Beer's law is obeyed over the terfenadine concentration range 0.2–1.2 mg/100 ml. The proposed methods have been successfully applied to the analysis of commercial terfenadine tablets.
ISSN:0039-9140
1873-3573
DOI:10.1016/0039-9140(88)80075-4