White matter microstructure underlying default mode network connectivity in the human brain

Resting state functional magnetic resonance imaging (fMRI) reveals a distinct network of correlated brain function representing a default mode state of the human brain. The underlying structural basis of this functional connectivity pattern is still widely unexplored. We combined fractional anisotro...

Full description

Saved in:
Bibliographic Details
Published in:NeuroImage (Orlando, Fla.) Fla.), 2010-02, Vol.49 (3), p.2021-2032
Main Authors: Teipel, Stefan J., Bokde, Arun L.W., Meindl, Thomas, Amaro, Edson, Soldner, Jasmin, Reiser, Maximilian F., Herpertz, Sabine C., Möller, Hans-Jürgen, Hampel, Harald
Format: Article
Language:English
Subjects:
Acquisitions & mergers
Aged
Aged, 80 and over
Brain
Brain - anatomy & histology
Brain function
Brain Mapping
Default mode
Diffusion Tensor Imaging
DTI
Female
Functional connectivity
Humans
Male
Microstructure
Middle Aged
Multivariate analysis
Neural Pathways - anatomy & histology
NMR
Nuclear magnetic resonance
Principal Component Analysis
Resting state fMRI
Structural connectivity
Studies
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Resting state functional magnetic resonance imaging (fMRI) reveals a distinct network of correlated brain function representing a default mode state of the human brain. The underlying structural basis of this functional connectivity pattern is still widely unexplored. We combined fractional anisotropy measures of fiber tract integrity derived from diffusion tensor imaging (DTI) and resting state fMRI data obtained at 3 Tesla from 20 healthy elderly subjects (56 to 83 years of age) to determine white matter microstructure underlying default mode connectivity. We hypothesized that the functional connectivity between the posterior cingulate and hippocampus from resting state fMRI data would be associated with the white matter microstructure in the cingulate bundle and fiber tracts connecting posterior cingulate gyrus with lateral temporal lobes, medial temporal lobes, and precuneus. This was demonstrated at the p
ISSN:1053-8119
1095-9572
DOI:10.1016/j.neuroimage.2009.10.067