Infection of less virulent Helicobacter pylori strains in asymptomatic healthy individuals in Thailand as a potential contributing factor to the Asian enigma

In Thailand, gastric cancer incidence is considerably low despite the high prevalence of Helicobacter pylori infection. We investigated the prevalence of H. pylori infection and the genotypes of cagA by using 179 stool specimens obtained from asymptomatic Thai individuals. In this study, the prevale...

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Bibliographic Details
Published in:Microbes and infection 2010-03, Vol.12 (3), p.227-230
Main Authors: Hirai, Itaru, Sasaki, Tadahiro, Kimoto, Ai, Yamamoto, Yoshimasa, Azuma, Takeshi, Mahachai, Varocha, Hansomburana, Piyathida, Lertkupinit, Comsun, Luangjaru, Somchai, Noophan, Phadet, Chanatrirattanapan, Rattikorn, Piyanirandr, Vanich, Sappajit, Theeranan, Suthivarakom, Karun, Sangsuk, Leelaowadee, Wangroongsarb, Piyada
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Antigens, Bacterial - genetics
Asymptomatic healthy individuals
Bacterial Proteins - genetics
Bacteriology
Biological and medical sciences
Carrier State - epidemiology
Carrier State - microbiology
Feces - microbiology
Female
Fundamental and applied biological sciences. Psychology
Gastric cancer incidence
Genotype
Genotyping
Helicobacter Infections - epidemiology
Helicobacter Infections - microbiology
Helicobacter pylori
Helicobacter pylori - pathogenicity
Humans
Male
Medical sciences
Microbiology
Middle Aged
Miscellaneous
Prevalence
Thai individuals
Thailand - epidemiology
Tumors
Virulence Factors - genetics
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Summary:In Thailand, gastric cancer incidence is considerably low despite the high prevalence of Helicobacter pylori infection. We investigated the prevalence of H. pylori infection and the genotypes of cagA by using 179 stool specimens obtained from asymptomatic Thai individuals. In this study, the prevalence of H. pylori infection was 43.6%, and the detection rate of cagA-positive strains was 43.5%. In addition, the proportion of the highly virulent East-Asian type of cagA was 7.2%. These results indicate that the low prevalence of cagA-positive H. pylori strain as well as the low prevalence of East-Asian genotype cagA-positive strains may contribute to the low gastric cancer incidence.
ISSN:1286-4579
1769-714X
DOI:10.1016/j.micinf.2009.12.007