Long-term results after resection for bone sarcoma pulmonary metastases

• Published in: European journal of cardio-thoracic surgery 2010-05, Vol.37 (5), p.1205-1208
• Main Authors: García Franco, Carlos E., Torre, Wenceslao, Tamura, Akiko, Guillén-Grima, Francisco, San-Julian, Mikel, Martin-Algarra, Salvador, Pardo, Francisco J.
• Format: Article
• Language: English
• Subjects: Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols - therapeutic use; Biological and medical sciences; Bone Neoplasms - pathology; Bone Neoplasms - therapy; Bone sarcoma; Cardiology. Vascular system; Child; Child, Preschool; Disease-free interval; Diseases of the osteoarticular system; Epidemiologic Methods; Female; Humans; Lung metastases; Lung Neoplasms - drug therapy; Lung Neoplasms - secondary; Lung Neoplasms - surgery; Male; Medical sciences; Middle Aged; Pneumology; Prognosis; Sarcoma - drug therapy; Sarcoma - secondary; Sarcoma - surgery; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases; Surgery of the heart; Treatment Outcome; Tumors of striated muscle and skeleton; Tumors of the respiratory system and mediastinum; Young Adult
• ISSN: 1010-7940; 1873-734X
• DOI: 10.1016/j.ejcts.2009.11.026

Background: Pulmonary metastases from bone sarcomas occur in approximately 40% of the cases. The combination of both chemotherapy and surgical resection is currently the standard treatment options for these patients. We aim to study the influence of different prognostic factors on long-term survival. Methods: We reviewed the prognostic factors and survival rate in 52 consecutive patients with pulmonary metastases from bone sarcomas. All of them were previously treated with chemotherapy and submitted to metastasectomy at our institution from 1996 to 2006. Clinical and demographic variables, related to the primary tumour as well as to the pulmonary metastases, and treatment procedures were registered. Univariate (log-rank) and multivariate (Cox regression) analysis were carried out to identify significant prognostic factors related to overall survival. Five-year survival rates were estimated using Kaplan–Meier methods. Results: Median follow-up was 28 months. Follow-up duration ranged 7–148 months; the median survival was 27 months. As many as 31% of the patients were alive without disease, 3% were alive with disease, 64% died of disease while 2% died from other causes. Complete resection was achieved in 49 cases (94%). The overall 3- and 5-year survival rates were 43% and 31%, respectively. Univariate analysis showed (1) disease-free interval between treatment of the primary bone tumour and first lung metastasectomy (DFI) and (2) disease-free interval between first and second lung surgery (DFI2) as prognostic factors. Gender, primary site, histology of primary tumour, surgical approach, number of lung nodules, type of lung resection and re-do lung surgery did not have a significant impact on survival. Conclusion: The long-term survival after bone sarcoma lung metastasectomy is encouraging. In our series, DFI and DFI2 were identified as the only prognostic factors.