Regulation of cerebral blood flow in mammals during chronic hypoxia: a matter of balance

Respiratory-induced changes in the partial pressures of arterial carbon dioxide and oxygen play a major role in cerebral blood flow (CBF) regulation. Elevations in (hypercapnia) lead to vasodilatation and increases in CBF, whereas reductions in (hypocapnia) lead to vasoconstriction and decreases in...

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Bibliographic Details
Published in:Experimental physiology 2010-02, Vol.95 (2), p.251-262
Main Authors: Ainslie, Philip N., Ogoh, Shigehiko
Format: Article
Language:English
Subjects:
Altitude
Altitude Sickness - physiopathology
Animals
Blood Flow Velocity
Brain - blood supply
Brain - physiopathology
Cerebrovascular Circulation
Chronic Disease
Homeostasis
Humans
Hypoxia - physiopathology
Models, Cardiovascular
Pulmonary Gas Exchange
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Summary:Respiratory-induced changes in the partial pressures of arterial carbon dioxide and oxygen play a major role in cerebral blood flow (CBF) regulation. Elevations in (hypercapnia) lead to vasodilatation and increases in CBF, whereas reductions in (hypocapnia) lead to vasoconstriction and decreases in CBF. A fall in (hypoxia) below a certain threshold (
ISSN:0958-0670
1469-445X
DOI:10.1113/expphysiol.2008.045575