Loading…
Paraventricular Hypothalamic Clonidine Increases Rather Than Decreases Susceptibility to Activity-Based Anorexia in the Rat
Anorexia has been related to reduced activity of the paraventricular hypothalamic (PVN) noradrenergic-feeding system. In this study we determined whether clonidine (an α2-adrenergic agonist) infused into the PVN reduced susceptibility to activity-based anorexia (ABA) in the rat. In Experiment 1, clo...
Saved in:
| Published in: | Behavioral neuroscience 1992-12, Vol.106 (6), p.1015-1022 |
|---|---|
| Main Authors: | , |
| Format: | Article |
| Language: | English |
| Subjects: | |
| Citations: | Items that cite this one |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| cited_by | cdi_FETCH-LOGICAL-a466t-9d40326541b6c7d6f30399df1f6d69ad3b91379a684f4e98ce6411c5329f44ee3 |
|---|---|
| cites | |
| container_end_page | 1022 |
| container_issue | 6 |
| container_start_page | 1015 |
| container_title | Behavioral neuroscience |
| container_volume | 106 |
| creator | Rieg, Thomas S Aravich, Paul F |
| description | Anorexia has been related to reduced activity of the paraventricular hypothalamic (PVN) noradrenergic-feeding system. In this study we determined whether clonidine (an α2-adrenergic agonist) infused into the PVN reduced susceptibility to activity-based anorexia (ABA) in the rat. In Experiment 1, clonidine (6 doses) was chronically infused into the PVN of male Sprague-Dawley rats. All animals were exposed to ABA (1.5 hr/day food access; 22.5 hr/day running wheel access) until a 25% body weight loss was reached. Dose-related increases in susceptibility to ABA and decreases in food intake were observed. In Experiment 2, for which heavier animals and 3 doses of clonidine were used, we found no difference in food intake and wheel activity but increased susceptibility to ABA. Chronic clonidine infused into the PVN does not produce hyperphagia and exacerbates rather than attenuates susceptibility to ABA. |
| doi_str_mv | 10.1037/0735-7044.106.6.1015 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_73395549</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>73395549</sourcerecordid><originalsourceid>FETCH-LOGICAL-a466t-9d40326541b6c7d6f30399df1f6d69ad3b91379a684f4e98ce6411c5329f44ee3</originalsourceid><addsrcrecordid>eNqFkU1v1DAQhi0EKkvhDyCQLIS4pdjxxImPy_LRSpVAtD1bE8dhXWWd1E4qVvx5HGVZEAe42B7PM6_H8xLygrMzzkT5lpWiyEoGkEJ5JtPKiwdkxZVQGWMVPCSrI_KYPInxljEGDIoTcsKFKHIpV-THFwx4b_0YnJk6DPR8P_TjFjvcOUM3Xe9d47ylF94Ei9FG-hXHrQ30eouevre_bq-maOwwutp1btzTsadrM7r7dM7eJaCha98H-90hdZ4mgVnmKXnUYhfts8N-Sm4-frjenGeXnz9dbNaXGYKUY6YaYCKXBfBamrKRrWBCqablrWykwkbUiotSoaygBasqYyVwbgqRqxbAWnFK3iy6Q-jvJhtHvXOp265Db_sp6lIIVRSg_gtyCVAu4Ku_wNt-Cj59QksOgueM5_-CciYqBUU5K8ECmdDHGGyrh-B2GPaaMz3brGcP9exhCqWWerY5lb08aE_1zja_ixZfU_71IY_RYNcG9MbFIwYAVS7n158vWIu9xm8hITdXSuQFpJkcp4ED6iHuDYbRmc5GXXv7ZzM_AdgTw8I</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>614312012</pqid></control><display><type>article</type><title>Paraventricular Hypothalamic Clonidine Increases Rather Than Decreases Susceptibility to Activity-Based Anorexia in the Rat</title><source>APA PsycARTICLES</source><creator>Rieg, Thomas S ; Aravich, Paul F</creator><creatorcontrib>Rieg, Thomas S ; Aravich, Paul F</creatorcontrib><description>Anorexia has been related to reduced activity of the paraventricular hypothalamic (PVN) noradrenergic-feeding system. In this study we determined whether clonidine (an α2-adrenergic agonist) infused into the PVN reduced susceptibility to activity-based anorexia (ABA) in the rat. In Experiment 1, clonidine (6 doses) was chronically infused into the PVN of male Sprague-Dawley rats. All animals were exposed to ABA (1.5 hr/day food access; 22.5 hr/day running wheel access) until a 25% body weight loss was reached. Dose-related increases in susceptibility to ABA and decreases in food intake were observed. In Experiment 2, for which heavier animals and 3 doses of clonidine were used, we found no difference in food intake and wheel activity but increased susceptibility to ABA. Chronic clonidine infused into the PVN does not produce hyperphagia and exacerbates rather than attenuates susceptibility to ABA.</description><identifier>ISSN: 0735-7044</identifier><identifier>EISSN: 1939-0084</identifier><identifier>DOI: 10.1037/0735-7044.106.6.1015</identifier><identifier>PMID: 1335266</identifier><identifier>CODEN: BENEDJ</identifier><language>eng</language><publisher>Washington, DC: American Psychological Association</publisher><subject>Activity Level ; Adult and adolescent clinical studies ; AGONISTS ; ALPHA-ADRENERGIC RECEPTORS ; Animal ; Animal Models ; Animals ; Anorexia ; Anorexia Nervosa ; APETITO ; APPETIT ; APPETITE ; Appetite - drug effects ; Biological and medical sciences ; Body Weight - drug effects ; BRAIN ; CEREBRO ; Clonidine ; Clonidine - pharmacology ; DIGESTIVE DISORDERS ; Dose-Response Relationship, Drug ; Eating behavior disorders ; ENCEPHALE ; ESTIMULO ; FOOD INTAKE ; HORMONE RECEPTORS ; Hunger - drug effects ; HYPOTHALAMUS ; INGESTION DE ALIMENTOS ; Male ; Medical research ; Medical sciences ; Motor Activity - drug effects ; Paraventricular Hypothalamic Nucleus - drug effects ; paraventricular noradrenergic feeding ; PRISE ALIMENTAIRE ; Psychology. Psychoanalysis. Psychiatry ; Psychopathology. Psychiatry ; RAT ; RATA ; RATS ; Rats, Sprague-Dawley ; RECEPTEUR D'HORMONE ; RECEPTORES DE HORMONAS ; Receptors, Adrenergic - drug effects ; Rodents ; STIMULATION ; STIMULI ; STIMULUS ; TRASTORNOS DIGESTIVOS ; TROUBLE DIGESTIF</subject><ispartof>Behavioral neuroscience, 1992-12, Vol.106 (6), p.1015-1022</ispartof><rights>1992 American Psychological Association</rights><rights>1993 INIST-CNRS</rights><rights>Copyright American Psychological Association Dec 1992</rights><rights>1992, American Psychological Association</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a466t-9d40326541b6c7d6f30399df1f6d69ad3b91379a684f4e98ce6411c5329f44ee3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=4448269$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1335266$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Rieg, Thomas S</creatorcontrib><creatorcontrib>Aravich, Paul F</creatorcontrib><title>Paraventricular Hypothalamic Clonidine Increases Rather Than Decreases Susceptibility to Activity-Based Anorexia in the Rat</title><title>Behavioral neuroscience</title><addtitle>Behav Neurosci</addtitle><description>Anorexia has been related to reduced activity of the paraventricular hypothalamic (PVN) noradrenergic-feeding system. In this study we determined whether clonidine (an α2-adrenergic agonist) infused into the PVN reduced susceptibility to activity-based anorexia (ABA) in the rat. In Experiment 1, clonidine (6 doses) was chronically infused into the PVN of male Sprague-Dawley rats. All animals were exposed to ABA (1.5 hr/day food access; 22.5 hr/day running wheel access) until a 25% body weight loss was reached. Dose-related increases in susceptibility to ABA and decreases in food intake were observed. In Experiment 2, for which heavier animals and 3 doses of clonidine were used, we found no difference in food intake and wheel activity but increased susceptibility to ABA. Chronic clonidine infused into the PVN does not produce hyperphagia and exacerbates rather than attenuates susceptibility to ABA.</description><subject>Activity Level</subject><subject>Adult and adolescent clinical studies</subject><subject>AGONISTS</subject><subject>ALPHA-ADRENERGIC RECEPTORS</subject><subject>Animal</subject><subject>Animal Models</subject><subject>Animals</subject><subject>Anorexia</subject><subject>Anorexia Nervosa</subject><subject>APETITO</subject><subject>APPETIT</subject><subject>APPETITE</subject><subject>Appetite - drug effects</subject><subject>Biological and medical sciences</subject><subject>Body Weight - drug effects</subject><subject>BRAIN</subject><subject>CEREBRO</subject><subject>Clonidine</subject><subject>Clonidine - pharmacology</subject><subject>DIGESTIVE DISORDERS</subject><subject>Dose-Response Relationship, Drug</subject><subject>Eating behavior disorders</subject><subject>ENCEPHALE</subject><subject>ESTIMULO</subject><subject>FOOD INTAKE</subject><subject>HORMONE RECEPTORS</subject><subject>Hunger - drug effects</subject><subject>HYPOTHALAMUS</subject><subject>INGESTION DE ALIMENTOS</subject><subject>Male</subject><subject>Medical research</subject><subject>Medical sciences</subject><subject>Motor Activity - drug effects</subject><subject>Paraventricular Hypothalamic Nucleus - drug effects</subject><subject>paraventricular noradrenergic feeding</subject><subject>PRISE ALIMENTAIRE</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychopathology. Psychiatry</subject><subject>RAT</subject><subject>RATA</subject><subject>RATS</subject><subject>Rats, Sprague-Dawley</subject><subject>RECEPTEUR D'HORMONE</subject><subject>RECEPTORES DE HORMONAS</subject><subject>Receptors, Adrenergic - drug effects</subject><subject>Rodents</subject><subject>STIMULATION</subject><subject>STIMULI</subject><subject>STIMULUS</subject><subject>TRASTORNOS DIGESTIVOS</subject><subject>TROUBLE DIGESTIF</subject><issn>0735-7044</issn><issn>1939-0084</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1992</creationdate><recordtype>article</recordtype><recordid>eNqFkU1v1DAQhi0EKkvhDyCQLIS4pdjxxImPy_LRSpVAtD1bE8dhXWWd1E4qVvx5HGVZEAe42B7PM6_H8xLygrMzzkT5lpWiyEoGkEJ5JtPKiwdkxZVQGWMVPCSrI_KYPInxljEGDIoTcsKFKHIpV-THFwx4b_0YnJk6DPR8P_TjFjvcOUM3Xe9d47ylF94Ei9FG-hXHrQ30eouevre_bq-maOwwutp1btzTsadrM7r7dM7eJaCha98H-90hdZ4mgVnmKXnUYhfts8N-Sm4-frjenGeXnz9dbNaXGYKUY6YaYCKXBfBamrKRrWBCqablrWykwkbUiotSoaygBasqYyVwbgqRqxbAWnFK3iy6Q-jvJhtHvXOp265Db_sp6lIIVRSg_gtyCVAu4Ku_wNt-Cj59QksOgueM5_-CciYqBUU5K8ECmdDHGGyrh-B2GPaaMz3brGcP9exhCqWWerY5lb08aE_1zja_ixZfU_71IY_RYNcG9MbFIwYAVS7n158vWIu9xm8hITdXSuQFpJkcp4ED6iHuDYbRmc5GXXv7ZzM_AdgTw8I</recordid><startdate>19921201</startdate><enddate>19921201</enddate><creator>Rieg, Thomas S</creator><creator>Aravich, Paul F</creator><general>American Psychological Association</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QG</scope><scope>7QR</scope><scope>7TK</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>7RZ</scope><scope>PSYQQ</scope><scope>7X8</scope></search><sort><creationdate>19921201</creationdate><title>Paraventricular Hypothalamic Clonidine Increases Rather Than Decreases Susceptibility to Activity-Based Anorexia in the Rat</title><author>Rieg, Thomas S ; Aravich, Paul F</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a466t-9d40326541b6c7d6f30399df1f6d69ad3b91379a684f4e98ce6411c5329f44ee3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1992</creationdate><topic>Activity Level</topic><topic>Adult and adolescent clinical studies</topic><topic>AGONISTS</topic><topic>ALPHA-ADRENERGIC RECEPTORS</topic><topic>Animal</topic><topic>Animal Models</topic><topic>Animals</topic><topic>Anorexia</topic><topic>Anorexia Nervosa</topic><topic>APETITO</topic><topic>APPETIT</topic><topic>APPETITE</topic><topic>Appetite - drug effects</topic><topic>Biological and medical sciences</topic><topic>Body Weight - drug effects</topic><topic>BRAIN</topic><topic>CEREBRO</topic><topic>Clonidine</topic><topic>Clonidine - pharmacology</topic><topic>DIGESTIVE DISORDERS</topic><topic>Dose-Response Relationship, Drug</topic><topic>Eating behavior disorders</topic><topic>ENCEPHALE</topic><topic>ESTIMULO</topic><topic>FOOD INTAKE</topic><topic>HORMONE RECEPTORS</topic><topic>Hunger - drug effects</topic><topic>HYPOTHALAMUS</topic><topic>INGESTION DE ALIMENTOS</topic><topic>Male</topic><topic>Medical research</topic><topic>Medical sciences</topic><topic>Motor Activity - drug effects</topic><topic>Paraventricular Hypothalamic Nucleus - drug effects</topic><topic>paraventricular noradrenergic feeding</topic><topic>PRISE ALIMENTAIRE</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychopathology. Psychiatry</topic><topic>RAT</topic><topic>RATA</topic><topic>RATS</topic><topic>Rats, Sprague-Dawley</topic><topic>RECEPTEUR D'HORMONE</topic><topic>RECEPTORES DE HORMONAS</topic><topic>Receptors, Adrenergic - drug effects</topic><topic>Rodents</topic><topic>STIMULATION</topic><topic>STIMULI</topic><topic>STIMULUS</topic><topic>TRASTORNOS DIGESTIVOS</topic><topic>TROUBLE DIGESTIF</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Rieg, Thomas S</creatorcontrib><creatorcontrib>Aravich, Paul F</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Animal Behavior Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>PsycArticles</collection><collection>ProQuest One Psychology</collection><collection>MEDLINE - Academic</collection><jtitle>Behavioral neuroscience</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rieg, Thomas S</au><au>Aravich, Paul F</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Paraventricular Hypothalamic Clonidine Increases Rather Than Decreases Susceptibility to Activity-Based Anorexia in the Rat</atitle><jtitle>Behavioral neuroscience</jtitle><addtitle>Behav Neurosci</addtitle><date>1992-12-01</date><risdate>1992</risdate><volume>106</volume><issue>6</issue><spage>1015</spage><epage>1022</epage><pages>1015-1022</pages><issn>0735-7044</issn><eissn>1939-0084</eissn><coden>BENEDJ</coden><abstract>Anorexia has been related to reduced activity of the paraventricular hypothalamic (PVN) noradrenergic-feeding system. In this study we determined whether clonidine (an α2-adrenergic agonist) infused into the PVN reduced susceptibility to activity-based anorexia (ABA) in the rat. In Experiment 1, clonidine (6 doses) was chronically infused into the PVN of male Sprague-Dawley rats. All animals were exposed to ABA (1.5 hr/day food access; 22.5 hr/day running wheel access) until a 25% body weight loss was reached. Dose-related increases in susceptibility to ABA and decreases in food intake were observed. In Experiment 2, for which heavier animals and 3 doses of clonidine were used, we found no difference in food intake and wheel activity but increased susceptibility to ABA. Chronic clonidine infused into the PVN does not produce hyperphagia and exacerbates rather than attenuates susceptibility to ABA.</abstract><cop>Washington, DC</cop><pub>American Psychological Association</pub><pmid>1335266</pmid><doi>10.1037/0735-7044.106.6.1015</doi><tpages>8</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0735-7044 |
| ispartof | Behavioral neuroscience, 1992-12, Vol.106 (6), p.1015-1022 |
| issn | 0735-7044 1939-0084 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_73395549 |
| source | APA PsycARTICLES |
| subjects | Activity Level Adult and adolescent clinical studies AGONISTS ALPHA-ADRENERGIC RECEPTORS Animal Animal Models Animals Anorexia Anorexia Nervosa APETITO APPETIT APPETITE Appetite - drug effects Biological and medical sciences Body Weight - drug effects BRAIN CEREBRO Clonidine Clonidine - pharmacology DIGESTIVE DISORDERS Dose-Response Relationship, Drug Eating behavior disorders ENCEPHALE ESTIMULO FOOD INTAKE HORMONE RECEPTORS Hunger - drug effects HYPOTHALAMUS INGESTION DE ALIMENTOS Male Medical research Medical sciences Motor Activity - drug effects Paraventricular Hypothalamic Nucleus - drug effects paraventricular noradrenergic feeding PRISE ALIMENTAIRE Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry RAT RATA RATS Rats, Sprague-Dawley RECEPTEUR D'HORMONE RECEPTORES DE HORMONAS Receptors, Adrenergic - drug effects Rodents STIMULATION STIMULI STIMULUS TRASTORNOS DIGESTIVOS TROUBLE DIGESTIF |
| title | Paraventricular Hypothalamic Clonidine Increases Rather Than Decreases Susceptibility to Activity-Based Anorexia in the Rat |
| url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-24T19%3A05%3A09IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Paraventricular%20Hypothalamic%20Clonidine%20Increases%20Rather%20Than%20Decreases%20Susceptibility%20to%20Activity-Based%20Anorexia%20in%20the%20Rat&rft.jtitle=Behavioral%20neuroscience&rft.au=Rieg,%20Thomas%20S&rft.date=1992-12-01&rft.volume=106&rft.issue=6&rft.spage=1015&rft.epage=1022&rft.pages=1015-1022&rft.issn=0735-7044&rft.eissn=1939-0084&rft.coden=BENEDJ&rft_id=info:doi/10.1037/0735-7044.106.6.1015&rft_dat=%3Cproquest_cross%3E73395549%3C/proquest_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-a466t-9d40326541b6c7d6f30399df1f6d69ad3b91379a684f4e98ce6411c5329f44ee3%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=614312012&rft_id=info:pmid/1335266&rfr_iscdi=true |