Acute effects of intravenously administered ethanol on retinal vessel diameters and flicker induced vasodilatation in healthy volunteers

• Published in: Microvascular research 2009-09, Vol.78 (2), p.224-229
• Main Authors: Luksch, Alexandra, Resch, Hemma, Weigert, Günther, Sacu, Stefan, Schmetterer, Leopold, Garhöfer, Gerhard
• Format: Article
• Language: English
• Subjects: Adult; Blood Pressure; Cross-Over Studies; Double-Blind Method; Ethanol; Ethanol - administration & dosage; Ethanol - pharmacology; Humans; Infusions, Intravenous; Intraocular Pressure - drug effects; Male; Neuro-vascular coupling; Ocular blood flow; Randomized Controlled Trials as Topic; Retinal vessel diameters; Retinal Vessels - physiology; Time Factors; Vasodilation - drug effects
• ISSN: 0026-2862; 1095-9319
• DOI: 10.1016/j.mvr.2009.06.001

There is evidence from several vascular beds that acute alcohol consumption causes ocular hypotension and peripheral vasodilatation. The current study investigated the effects of intravenously administered ethanol on retinal vessel diameters and on flicker induced retinal vasodilatation. For this purpose, ethanol (0.35 g/kg) or placebo (physiologic saline solution) was administered intravenously for 40 min in a randomized, double masked, two way cross-over design to 12 healthy male volunteers. Retinal vessel diameters and flicker induced vasodilatation were measured before administration of ethanol as well as 30, 50, 90 and 130 min after the start of infusion with a retinal vessel analyzer. Intraocular pressure, systemic blood pressure and blood ethanol concentration were determined at the same time points. Intravenous administration of ethanol increased blood ethanol concentration from 0.0 g/l to 0.56 ± 0.10 g/l. Ethanol reduced IOP, but did not change ocular perfusion pressure. After cessation of the infusion blood ethanol concentration started to drop reaching a blood ethanol concentration of 0.22 ± 0.06 g/l 130 min after the start of infusion. Retinal arterial diameters increased significantly after administration of ethanol by a maximum of + 4.2 ± 4.0%, whereas no change was observed in retinal veins. Neither arterial nor venous diameters were influenced by administration of placebo. Flicker stimulation induced a significant dilatation in both arterial and venous diameters. Ethanol did not change flicker responses in arteries or in retinal veins. In conclusion, intravenous administration of ethanol increases retinal arterial diameters, whereas venous diameters remained unchanged. Whether this is related to a direct vasodilator effect or to a hitherto unidentified mechanism remains to be clarified.