Comparison of turbo-PUVA and conventional American-style PUVA in the treatment of psoriatic patients

Background: Ultraviolet (UV)A protective properties of dihydroxyacetone (DHA) have been used as a topical UV‐resisting barrier to optimize psoralens and UVA (turbo‐PUVA). Starting doses and increments were based on the DHA diffuse reflectance spectroscopy‐derived protection factor. Objective: To eva...

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Bibliographic Details
Published in:Photodermatology, photoimmunology & photomedicine photoimmunology & photomedicine, 2010-08, Vol.26 (4), p.205-210
Main Authors: Moneib, Hoda Ahmed M., Salem, Samar Aballah Mohamed, Younis, Rehab Mohamed Mounir
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Biological and medical sciences
Dermatology
dihydroxyacetone
Female
Humans
Male
Medical sciences
Middle Aged
Photosensitizing Agents - therapeutic use
psoriasis
Psoriasis - drug therapy
Psoriasis. Parapsoriasis. Lichen
PUVA Therapy - methods
treatment
turbo-PUVA
Young Adult
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Summary:Background: Ultraviolet (UV)A protective properties of dihydroxyacetone (DHA) have been used as a topical UV‐resisting barrier to optimize psoralens and UVA (turbo‐PUVA). Starting doses and increments were based on the DHA diffuse reflectance spectroscopy‐derived protection factor. Objective: To evaluate the efficacy of turbo‐PUVA in psoriatic patients using a simpler method for determining starting doses and increments, in comparison to the conventional American‐style PUVA photochemotherapy. Methods: Thirty psoriasis patients (15 on American‐style PUVA and 15 on turbo‐PUVA) were evaluated, each receiving PUVA twice weekly. Starting UVA dose was determined according to skin phototype for the American‐style PUVA group and according to the patient's skin phototype × DHA SPF 3 in turbo‐PUVA group. UVA increments used were 0.5–1.5 J/cm2 per treatment in American‐style PUVA and 25% of the previous dose in turbo‐PUVA. Results: Turbo‐PUVA group showed a significantly lower mean cumulative dose, a significantly higher psoriasis area and severity index score reduction, lesser mean number of treatment sessions, and less duration of treatment till remission (188.44±106.2 J/cm2, 92.164±1.975%, 11.2±3.52 session, and 1.4±0.44 months, respectively) than conventional American‐style PUVA group (255.13±18.304 J/cm2, 74.725±10.976%, 30±0.00 sessions, and 3.75±0.00 months, respectively). Conclusion: Turbo‐PUVA is more effective and time convenient for the treatment of psoriasis with less cumulative dose than the conventional American‐style PUVA.
ISSN:0905-4383
1600-0781
DOI:10.1111/j.1600-0781.2010.00523.x