Fetuin-A promotes primary keratinocyte migration: independent of epidermal growth factor receptor signalling

Please cite this paper as: Fetuin‐A promotes primary keratinocyte migration: independent of epidermal growth factor receptor signalling. Experimental Dermatology 2010; 19: e289–e292. :  Previously, we reported that fetuin‐A is a major component of ovine foetal skin and significantly enhances ‘wound...

Full description

Saved in:
Bibliographic Details
Published in:Experimental dermatology 2010-08, Vol.19 (8), p.e289-e292
Main Authors: Wang, Xue-Qing, Hung, Betsy S., Kempf, Margit, Liu, Pei-Yun, Dalley, Andrew J., Saunders, Nicholas A., Kimble, Roy M.
Format: Article
Language:English
Subjects:
alpha-2-HS-Glycoprotein
Blood Proteins - pharmacology
burn treatment
Cell Line
Cell Movement - drug effects
Dose-Response Relationship, Drug
Epidermal Growth Factor
Humans
keratinocyte migration
Keratinocytes - cytology
Keratinocytes - drug effects
Keratinocytes - metabolism
re-epithelialisation
Receptor, Epidermal Growth Factor - metabolism
Signal Transduction - physiology
Transforming Growth Factor alpha
wound healing
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Please cite this paper as: Fetuin‐A promotes primary keratinocyte migration: independent of epidermal growth factor receptor signalling. Experimental Dermatology 2010; 19: e289–e292. :  Previously, we reported that fetuin‐A is a major component of ovine foetal skin and significantly enhances ‘wound closure’ in primary keratinocyte cultures. In this study, we found that in human newborn foreskin, a high level of fetuin‐A protein is detected throughout the dermis. However, in adult skin a low level of fetuin‐A is observed throughout the epidermal and dermal layers, except at regions surrounding hair follicles and at the epidermal‐dermal junction where the level of fetuin‐A is relatively high. Fetuin‐A significantly induces actin‐rich protrusions in human primary keratinocytes. Interestingly, blockade of epidermal growth factor (EGF) receptor signalling has a limited effect on fetuin‐A promoted ‘wound closure’ on primary human keratinocytes, but significantly inhibits fetuin‐A’s effect on HaCaT cells. These results indicate that high levels of fetuin‐A may partially contribute to less scar formation in newborn foreskin and that the effect of fetuin‐A on primary keratinocyte migration is independent of EGF receptor signalling.
ISSN:0906-6705
1600-0625
DOI:10.1111/j.1600-0625.2009.00978.x