Beginning Hemodialysis: Do Patients With a Failed Renal Transplant Start in Worse Condition?

• Published in: Transplantation proceedings 2009-07, Vol.41 (6), p.2129-2131
• Main Authors: Beltrán, S, Gavela, E, Kanter, J, Sancho, A, Ávila, A, Górriz, J.L, Crespo, J.F, Pallardó, L.M
• Format: Article
• Language: English
• Subjects: Adult; Aged; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy; Antihypertensive Agents - therapeutic use; Biological and medical sciences; Blood Chemical Analysis; Blood Pressure; Cholesterol - blood; Drug Resistance; Emergency and intensive care: renal failure. Dialysis management; Erythropoietin - adverse effects; Erythropoietin - therapeutic use; Female; Follow-Up Studies; Fundamental and applied biological sciences. Psychology; Fundamental immunology; Glomerular Filtration Rate; Humans; Intensive care medicine; Kidney Transplantation - adverse effects; Male; Medical sciences; Middle Aged; Patient Selection; Renal Dialysis - statistics & numerical data; Retrospective Studies; Surgery; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases; Time Factors; Tissue, organ and graft immunology; Transplantation, Homologous - adverse effects; Treatment Failure; Treatment Outcome
• ISSN: 0041-1345; 1873-2623
• DOI: 10.1016/j.transproceed.2009.06.006

Abstract Objective Predialysis management of patients with kidney transplant failure is a topic of growing interest. Herein we have reviewed a group of patients with a failed kidney transplant who returned to dialysis to compare them with patients with native kidney failure. Patients and Methods We analyzed 25 patients who returned to dialysis after a failed renal transplant (group A) and 38 patients initiating dialysis after native kidney failure (group B). Results We did not observe significant differences in the glomerular filtration rate (GFR), potassium, calcium, phosphorus, albumin, and hemoglobin levels between the 2 groups at the beginning of dialysis. Erythropoietin resistance index (ERI) was higher in group A. Progression of renal disease in the 2 years before dialysis was faster in group A, with a greater monthly decline in GFR and higher levels of systolic blood pressure. Renal transplant patients needed more evaluations in the 6 months before initiating dialysis: 1.75 ± 0.97 vs 0.70 ± 2.61 evaluations/month ( P = .000). Also, the number of hospitalizations during the years before and after dialysis initiation was higher among group A. Patient survival after return to dialysis at 1 year was 75% in group A and 97% in group B (log-rank; P = .09). Conclusions Patients with a failed kidney allograft initiated dialysis in similar condition to those with native kidney failure. The faster GFR decline may be related to immunosuppressive treatment. Transplant patients needed more frequent evaluations and more hospitalizations before and after dialysis initiation, indicating a higher morbidity rate.