Norepinephrine and cardiovascular responses to maximal exercise in Parkinson's disease on and off medication

The aim of this experiment is to understand how Parkinson's disease (PD) medication affects the autonomic responses of individuals during an acute exercise stress test. Fourteen people with PD and fifteen healthy individuals age‐matched between 50 and 80 years performed a modified Bruce protoco...

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Bibliographic Details
Published in:Movement disorders 2009-09, Vol.24 (12), p.1773-1778
Main Authors: DiFrancisco-Donoghue, Joanne, Elokda, Ahmed, Lamberg, Eric M., Bono, Nancy, Werner, William G.
Format: Article
Language:English
Subjects:
Aged
Aged, 80 and over
Analysis of Variance
autonomic cardiac abnormalities
Biological and medical sciences
blood pressure
Blood Pressure - drug effects
Blood Pressure - physiology
Cardiovascular System - drug effects
Cardiovascular System - physiopathology
Case-Control Studies
Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases
Electrocardiography
Exercise - physiology
exercise test
Exercise Test - methods
Female
heart rate
Heart Rate - drug effects
Heart Rate - physiology
Humans
levodopa
Male
Medical sciences
Middle Aged
Neurology
Norepinephrine - metabolism
Parkinson Disease - drug therapy
Parkinson Disease - physiopathology
peak VO2
Statistics, Nonparametric
sympathetic nervous system
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Summary:The aim of this experiment is to understand how Parkinson's disease (PD) medication affects the autonomic responses of individuals during an acute exercise stress test. Fourteen people with PD and fifteen healthy individuals age‐matched between 50 and 80 years performed a modified Bruce protocol. Subjects with PD performed the test once off medication (PD‐off) and then 1 week later on medication (PD‐on). Heart rate (HR), blood pressure (BP), VO2, and norepinephrine (NE) levels were taken at rest and at peak exercise. At peak exercise HR, BP, and NE values for the PD‐on and PD‐off group were all significantly lower than healthy controls, regardless of whether subjects were on their medication. Autonomic abnormalities during exercise in this population appear to be disease manifested and not impactedby medications used to treat PD. We can assume, both on and off medication, this population will show markedly lower BP, HR, and NE responses. © 2009 Movement Disorder Society
ISSN:0885-3185
1531-8257
DOI:10.1002/mds.22612