Ion-exchange resins as drug delivery carriers

There are many reports in the literature referring to the utilization of drug bound to ion-exchange resin (drug–resinate), especially in the drug delivery area. Ion-exchange resin complexes, which can be prepared from both acidic and basic drugs, have been widely studied and marketed. Salts of catio...

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Bibliographic Details
Published in:Journal of pharmaceutical sciences 2009-11, Vol.98 (11), p.3886-3902
Main Authors: Guo, Xiaodi, Chang, Rong-Kun, Hussain, Munir A.
Format: Article
Language:English
Subjects:
anion-exchange
Biological and medical sciences
cation-exchange
Cross-Linking Reagents - chemistry
desorption
dissolution
Drug Carriers
drug delivery
Drug Delivery Systems
General pharmacology
Ion Exchange Resins - administration & dosage
Ion Exchange Resins - chemistry
Medical sciences
microencapsulation
Particle Size
Pharmaceutical technology. Pharmaceutical industry
Pharmacology. Drug treatments
polymers
Polymers - chemistry
resin
sorption
sustained-release
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Summary:There are many reports in the literature referring to the utilization of drug bound to ion-exchange resin (drug–resinate), especially in the drug delivery area. Ion-exchange resin complexes, which can be prepared from both acidic and basic drugs, have been widely studied and marketed. Salts of cationic and anionic exchange resins are insoluble complexes in which drug release results from exchange of bound drug ions by ions normally present in body fluids. Resins used are polymers that contain appropriately substituted acidic groups, such as carboxylic and sulfonic for cation exchangers; or basic groups, such as quaternary ammonium group for anion exchangers. Variables relating to the resin are the exchange capacity; degree of cross-linking, which determines the permeability of the resin, its swelling potential, and the access of the exchange sites to the drug ion; the effective pKa of the exchanging group, which determines the exchange affinity; and the resin particle size, which controls accessibility to the exchange ions. In this review, the properties of ion-exchange resins, selection of drugs that lend themselves to such an approach, selection of the appropriate resin, preparation of drug–resinate, evaluation of drug release, recent developments of drug–resinates, and applications are discussed. © 2009 Wiley-Liss, Inc. and the American Pharmacists Association J Pharm Sci 98:3886–3902, 2009
ISSN:0022-3549
1520-6017
1520-6017
DOI:10.1002/jps.21706