Methylphenidate normalises activation and functional connectivity deficits in attention and motivation networks in medication-naïve children with ADHD during a rewarded continuous performance task

Children with Attention Deficit Hyperactivity Disorder (ADHD) have deficits in motivation and attention that can be ameliorated with the indirect dopamine agonist Methylphenidate (MPH). We used functional magnetic resonance imaging (fMRI) to investigate the effects of MPH in medication-naïve childre...

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Bibliographic Details
Published in:Neuropharmacology 2009-12, Vol.57 (7), p.640-652
Main Authors: Rubia, Katya, Halari, Rozmin, Cubillo, Ana, Mohammad, Abdul-Majeed, Brammer, Mick, Taylor, Eric
Format: Article
Language:English
Subjects:
Adolescent
Attention - drug effects
Attention Deficit Disorder with Hyperactivity - drug therapy
Attention Deficit Disorder with Hyperactivity - physiopathology
Attention Deficit Disorder with Hyperactivity - psychology
Attention deficit hyperactivity disorder (ADHD)
Brain - drug effects
Brain - physiopathology
Central Nervous System Stimulants - pharmacology
Central Nervous System Stimulants - therapeutic use
Child
Continuous performance task
Corpus Striatum - drug effects
Corpus Striatum - physiopathology
fMRI
Frontal Lobe - drug effects
Frontal Lobe - physiopathology
Functional connectivity
Humans
Magnetic Resonance Imaging
Male
Methylphenidate
Methylphenidate - pharmacology
Methylphenidate - therapeutic use
Motivation - drug effects
Neuropsychological Tests
Parietal Lobe - drug effects
Parietal Lobe - physiopathology
Reward
Sustained attention
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