Circulating Soluble SR-PSOX/CXCL16 as a Biomarker for Acute Coronary Syndrome -Comparison with High-Sensitivity C-Reactive Protein

Aim: Diagnostic values of soluble SR-PSOX/CXCL16 (sSR-PSOX/CXCL16), a receptor for atherogenic oxidized LDL and a membrane-anchored chemokine for CXCR6-positive lymphocytes, for acute coronary syndrome (ACS) were evaluated. .Methods: We examined 106 patients undergoing coronary angiography (CAG); 17...

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Published in:Journal of Atherosclerosis and Thrombosis 2009, Vol.16(5), pp.586-593
Main Authors: Mitsuoka, Hirokazu, Toyohara, Masako, Kume, Noriaki, Hayashida, Kazutaka, Jinnai, Toshikazu, Tanaka, Masaru, Kita, Toru
Format: Article
Language:English
Subjects:
Acute Coronary Syndrome - blood
Aged
Biomarkers - blood
C-Reactive Protein - analysis
Chemokine CXCL16
Chemokines
Chemokines, CXC - blood
Coronary Angiography
Enzyme-Linked Immunosorbent Assay
Female
Humans
Male
Middle Aged
Oxidized LDL
Plaque rupture
Receptors, Scavenger - blood
ROC Curve
Scavenger receptors
Sensitivity and Specificity
Solubility
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Summary:Aim: Diagnostic values of soluble SR-PSOX/CXCL16 (sSR-PSOX/CXCL16), a receptor for atherogenic oxidized LDL and a membrane-anchored chemokine for CXCR6-positive lymphocytes, for acute coronary syndrome (ACS) were evaluated. .Methods: We examined 106 patients undergoing coronary angiography (CAG); 17 patients with ACS and 89 patients without ACS (non-ACS) including stable angina. Circulating sSR-SPOX/CXCL16 was measured in peripheral venous blood by sandwich ELISA. Results: Age, gender, prevalence of diabetes or hypertension, and serum lipid profiles were not significantly different between ACS and non-ACS. Presence or absence of risk factors, such as diabetes, smoking and hypertension, did not significantly affect circulating sSR-PSOX/CXCL16 levels. Circulating sSR-PSOX/CXCL16 levels were significantly lower in ACS than non-ACS (median: 3.05 versus 3.36 ng/mL, p
ISSN:1340-3478
1880-3873
DOI:10.5551/jat.1081