Isocaloric high-protein diet as well as branched-chain amino acids supplemented diet partially alleviates adverse consequences of maternal undernutrition on fetal growth

Abstract Maternal undernutrition causes fetal growth restriction. Protein is a vital dietary nutrient for fetal growth, and branched-chain amino acids (BCAA) are noted to have anabolic actions. In this study, we investigated the effects of maternal high-protein diet or BCAA-supplemented diet upon fe...

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Published in:Growth hormone & IGF research 2009-12, Vol.19 (6), p.478-485
Main Authors: Mogami, Haruta, Yura, Shigeo, Itoh, Hiroaki, Kawamura, Makoto, Fujii, Tsuyoshi, Suzuki, Ayako, Aoe, Seiichiro, Ogawa, Yoshihiro, Sagawa, Norimasa, Konishi, Ikuo, Fujii, Shingo
Format: Article
Language:English
Subjects:
Advanced Basic Science
Amino Acids, Branched-Chain - chemistry
Animal Nutrition Sciences
Animals
Branched-chain amino acids
Caloric Restriction
Dietary Supplements
Endocrinology & Metabolism
Female
Fetal Development
Fetal growth
Fetal Growth Retardation - etiology
Fetal Weight
High-protein diet
Insulin-Like Growth Factor I - metabolism
Insulin-Like Growth Factor II - metabolism
Insulin-like growth factors
Liver - embryology
Maternal Exposure
Maternal nutrition
Mice
Mice, Inbred C57BL
Pregnancy
Pregnancy, Animal
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Summary:Abstract Maternal undernutrition causes fetal growth restriction. Protein is a vital dietary nutrient for fetal growth, and branched-chain amino acids (BCAA) are noted to have anabolic actions. In this study, we investigated the effects of maternal high-protein diet or BCAA-supplemented diet upon fetal growth under the condition of maternal calorie restriction. Pregnant mice were calorie-restricted (undernutrition: UN), using either a standard diet (S-UN group), high-protein diet (HP-UN group), or BCAA-supplemented diet (BCAA-UN group) to 70% of the control; dams fed ad libitum with a standard diet (S-NN group) from 10.5 days post coitum (dpc) to 18.5 dpc. The fetal weights of UN groups were significantly decreased compared to that of S-NN. However, the fetal weights of HP-UN and BCAA-UN were significantly higher by 5% and 4%, respectively, than those of S-UN, concomitant with augmentation of the gene and protein expressions of IGF-I and IGF-II in fetal liver. A high-protein diet as well as BCAA-supplemented diet partially improved fetal growth restriction caused by maternal calorie-restriction, suggesting a pivotal role of them in the amelioration of fetal growth restriction.
ISSN:1096-6374
1532-2238
DOI:10.1016/j.ghir.2009.03.002