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Visceral obesity is characterized by impaired nitric oxide-independent vasodilation

Background Endothelial dysfunction has been described in obesity. This study examines the impact of visceral obesity on nitric oxide-independent relaxation in the human forearm. Methods and results In ten viscerally obese and ten matched controls forearm blood flow (FBF) was measured by venous occlu...

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Bibliographic Details
Published in:European heart journal 2003-07, Vol.24 (13), p.1210-1215
Main Authors: Vigili de Kreutzenberg, S., Kiwanuka, E., Tiengo, A., Avogaro, A.
Format: Article
Language:English
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Summary:Background Endothelial dysfunction has been described in obesity. This study examines the impact of visceral obesity on nitric oxide-independent relaxation in the human forearm. Methods and results In ten viscerally obese and ten matched controls forearm blood flow (FBF) was measured by venous occlusion plethysmography during intrabrachial infusion of: (1) sodium nitroprusside; (2) bradykinin, before and after inhibition of vasoactive prostaglandins and nitric oxide; (3) potassium; (4) ouabain (Na+/K+ATPase inhibitor) alone or (5) in combination with BaCl2(KIRinhibitor). Baseline FBF and endothelium-independent vasodilatation were similar in the two groups. In obese patients, bradykinin-induced increase of FBF was significantly less than in controls (P
ISSN:0195-668X
1522-9645
DOI:10.1016/S0195-668X(03)00206-9