Bone marrow–derived cells from male donors can compose endometrial glands in female transplant recipients

Objective For continuous regeneration of human endometrium in menstrual cycles, endometrial stem cells are assumed to supply differentiating endometrial glandular cells. To elucidate the origin of endometrial stem cells, we examined the presence of donor-derived cells in endometria from patients who...

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Bibliographic Details
Published in:American journal of obstetrics and gynecology 2009-12, Vol.201 (6), p.608.e1-608.e8
Main Authors: Ikoma, Tomomi, MD, Kyo, Satoru, MD, PhD, Maida, Yoshiko, MD, PhD, Ozaki, Satoru, PhD, Takakura, Masahiro, MD, PhD, Nakao, Shinji, MD, PhD, Inoue, Masaki, MD, PhD
Format: Article
Language:English
Subjects:
Adult
Biological and medical sciences
Biopsy
Bone Marrow Cells - pathology
bone marrow transplant
Bone Marrow Transplantation
Cell Differentiation
endometrium
Endometrium - pathology
Female
fluorescent in situ hybridization
Gynecology. Andrology. Obstetrics
Hormone Replacement Therapy
Humans
Male
Medical sciences
Obstetrics and Gynecology
Sex Factors
stem cell
Tissue Donors
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Summary:Objective For continuous regeneration of human endometrium in menstrual cycles, endometrial stem cells are assumed to supply differentiating endometrial glandular cells. To elucidate the origin of endometrial stem cells, we examined the presence of donor-derived cells in endometria from patients who received bone marrow transplantation from male donors. Study Design Endometrial specimens biopsied after hormone replacement therapy were obtained and examined using fluorescent in situ hybridization analysis targeting X or Y chromosomes. Results All recipients had donor-derived Y chromosome–positive endometrial cells, accounting for 0.6-8.4% of glandular epithelial cells and 8.2-9.8% of stromal cells. Most of the endometrial glands were chimeric, consisting of both donor-derived and recipient cells. Conclusion Donor-derived cells are capable of composing endometrium in recipients, even those of the opposite sex. These results suggest unexpected plasticity of bone marrow stem cells as well as a potential origin of endometrial stem cells.
ISSN:0002-9378
1097-6868
DOI:10.1016/j.ajog.2009.07.026