Serum Long-Chain n-3 Polyunsaturated Fatty Acids and Risk of Hospital Diagnosis of Atrial Fibrillation in Men

Atrial fibrillation (AF) is a common cardiac arrhythmia. Regular fish consumption has been shown to reduce the risk of AF in some but not all studies. Long-chain n-3 polyunsaturated fatty acids (PUFAs) from fish have been suggested to account for these beneficial effects. We tested this hypothesis b...

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Bibliographic Details
Published in:Circulation (New York, N.Y.) N.Y.), 2009-12, Vol.120 (23), p.2315-2321
Main Authors: VIRTANEN, Jyrki K, MURSU, Jaakko, VOUTILAINEN, Sari, TUOMAINEN, Tomi-Pekka
Format: Article
Language:English
Subjects:
Adult
Atrial Fibrillation - blood
Atrial Fibrillation - diagnosis
Atrial Fibrillation - prevention & control
Biological and medical sciences
Biomarkers - blood
Blood and lymphatic vessels
Cardiology. Vascular system
Cohort Studies
Dietary Fats, Unsaturated - administration & dosage
Dietary Fats, Unsaturated - blood
Diseases of the lymphatic vessels
Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous
Fatty Acids, Omega-3 - administration & dosage
Fatty Acids, Omega-3 - blood
Fatty Acids, Unsaturated - administration & dosage
Fatty Acids, Unsaturated - blood
Follow-Up Studies
Hospitalization
Humans
Male
Medical sciences
Middle Aged
Prospective Studies
Risk Factors
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Summary:Atrial fibrillation (AF) is a common cardiac arrhythmia. Regular fish consumption has been shown to reduce the risk of AF in some but not all studies. Long-chain n-3 polyunsaturated fatty acids (PUFAs) from fish have been suggested to account for these beneficial effects. We tested this hypothesis by studying the association between the serum long-chain n-3 PUFAs eicosapentaenoic acid, docosapentaenoic acid, and docosahexaenoic acid and risk of AF in men. A total of 2174 men from the prospective population-based Kuopio Ischemic Heart Disease Risk Factor Study, 42 to 60 years old and free of AF at baseline in 1984 to 1989, were studied. During the average follow-up time of 17.7 years, 240 AF events occurred. In the Cox proportional hazards model, the multivariable-adjusted hazard ratio in the highest (>5.33%) versus the lowest (
ISSN:0009-7322
1524-4539
DOI:10.1161/CIRCULATIONAHA.109.852657