How Does Trichinella spiralis Make Itself at Home?

The nurse cell–parasite complex of Trichinella spiralis is unlike anything else in Nature. It is derived from a normal portion of striated skeletal muscle cell and develops in a matter of 15 to 20 days after the larva invades that cell type. What are the molecular mechanisms at work that result in t...

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Bibliographic Details
Published in:Parasitology today (Regular ed.) 1998-08, Vol.14 (8), p.318-323
Main Author: Despommier, D.D
Format: Article
Language:English
Subjects:
Biological and medical sciences
circulatory rete
collagen capsule
Fundamental and applied biological sciences. Psychology
Host parasite relation
pathogenicity
Invertebrates
Nemathelminthia. Plathelmintha
nurse cell
signalling molecules
Trichinella spiralis
tyvelosylated secreted peptides
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Summary:The nurse cell–parasite complex of Trichinella spiralis is unlike anything else in Nature. It is derived from a normal portion of striated skeletal muscle cell and develops in a matter of 15 to 20 days after the larva invades that cell type. What are the molecular mechanisms at work that result in this unique relationship? Here, Dickson Despommier presents a hypothesis to account for its formation, in which secreted tyvelosylated proteins of the larva play a central role. These proteins are always present in the intracellular niche of the larva from Day 7 after infection and may be responsible for redirecting host genomic expression, leading to nurse cell formation.
ISSN:0169-4758
1873-1473
DOI:10.1016/S0169-4758(98)01287-3