Genotyping of rotavirus isolates collected from children less than 5 years of age admitted for diarrhoea at the Yangon Children's Hospital, Myanmar

• Published in: Vaccine 2009-11, Vol.27, p.F89-F92
• Main Authors: Moe, Kyaw, Thu, Hlaing Myat, Oo, Win Mar, Aye, Khin Mar, Shwe, Thin Thin, Mar, Win, Kirkwood, Carl D
• Format: Article
• Language: English
• Subjects: Age Distribution; Allergy and Immunology; Child, Preschool; Diarrhea - epidemiology; Diarrhea - virology; Gastroenteritis - epidemiology; Gastroenteritis - virology; Genotype; Genotype distribution; Hospitals, Pediatric; Humans; Incidence; Infant; Molecular Epidemiology; Myanmar - epidemiology; Prevalence; Rotavirus; Rotavirus - genetics; Rotavirus - isolation & purification; Rotavirus Infections - epidemiology; Seasons
• ISSN: 0264-410X; 1873-2518
• DOI: 10.1016/j.vaccine.2009.08.068

Abstract Rotavirus positive stool specimens collected from children less than 5-year-old admitted to Yangon Children's Hospital for diarrhoea were analysed for their G and P genotypes. In 2004, rotavirus was detected in 57% of 1004 samples tested with G3 and P[8] being the most common genotypes identified. Corresponding figures in 2005, were 55% of 1175 samples positive for rotavirus with G3 and P[4] genotypes being most common. The most common G and P combinations were G3P[8] and G1P[8], with some unusual combinations (G1P[4], G1P[6] and G3P[4]) also being identified. In Myanmar, ongoing rotavirus surveillance to understand the distribution of G and P genotypes will be important for monitoring the impact of rotavirus vaccines following their introduction into the infant immunization schedule.