Strains of Mycobacterium avium differentially activate human dendritic cells

Animal models indicate that exposure to environmental strains of mycobacteria can modulate immune responses and influence the effectiveness of live mycobacterial vaccines. Here, we describe that between the two recently reported Mycobacterium avium isolates, strain WAg 206 (but not strain WAg 207) i...

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Bibliographic Details
Published in:Immunology and cell biology 2010-01, Vol.88 (1), p.95-98
Main Authors: Buchan, Glenn S, Lee, Rachel, Wilson, Michelle, Slobbe, Lynn, Buddle, Bryce M, Young, Sarah L
Format: Article
Language:English
Subjects:
antigen presentation
Antigens, CD - immunology
Cell Differentiation
Cells, Cultured
Cytokines - immunology
dendritic cell
Dendritic Cells - cytology
Dendritic Cells - immunology
HLA Antigens - immunology
Humans
microbial regulation
Monocytes - cytology
Monocytes - immunology
Mycobacterium avium
Mycobacterium avium - growth & development
Mycobacterium avium - immunology
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Summary:Animal models indicate that exposure to environmental strains of mycobacteria can modulate immune responses and influence the effectiveness of live mycobacterial vaccines. Here, we describe that between the two recently reported Mycobacterium avium isolates, strain WAg 206 (but not strain WAg 207) interferes with human monocyte‐derived dendritic cell (MDDC) activation. WAg 206, unlike WAg 207, did not elicit inflammatory cytokine production (TNFα, IL‐1β, IL‐12) or costimulatory molecule expression (HLA‐DR, CD83, CD80, CD86) by human MDDCs in vitro. These data highlight the potential for environmental mycobacteria to modulate immune responses in humans, and suggest a mechanism by which earlier exposure to such microbes may compromise the efficacy of live mycobacterial vaccines, as has been observed in some human BCG vaccine trials.
ISSN:0818-9641
1440-1711
DOI:10.1038/icb.2009.51