Dietary restriction in nonhuman primates: progress report on the NIA study

Rhesus and squirrel monkeys have been fed a semisynthetic diet at approximately ad libitum or 30% reduced levels for 3.5 (rhesus group 2) to 4.5 (rhesus group 1 and squirrel) years. Animals have maintained excellent health status as determined by physical examinations, hematology, and blood chemistr...

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Bibliographic Details
Published in:Annals of the New York Academy of Sciences 1992-12, Vol.673 (1), p.36-45
Main Authors: Lane, M.A. (National Institute on Aging, Baltimore, MD), Ingram, D.K, Cutler, R.G, Knapka, J.J, Barnard, D.E, Roth, G.S
Format: Article
Language:English
Subjects:
AGING
Aging - metabolism
Aging - physiology
ALIMENTACION RACIONADA
ALIMENTATION RATIONNEE
Alkaline Phosphatase - blood
Animals
Body Height
Body Weight
DIET
DIET STUDIES
DIETA
ENVEJECIMIENTO
HUMAN NUTRITION
INVESTIGACION
Macaca mulatta - physiology
Male
MONKEYS
MONO
national institute on aging (nia)
National Institutes of Health (U.S.)
NUTRICION HUMANA
NUTRITION HUMAINE
RECHERCHE
REGIME ALIMENTAIRE
RESTRICTED FEEDING
Saimiri - physiology
SINGE
United States
VIEILLISSEMENT
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Summary:Rhesus and squirrel monkeys have been fed a semisynthetic diet at approximately ad libitum or 30% reduced levels for 3.5 (rhesus group 2) to 4.5 (rhesus group 1 and squirrel) years. Animals have maintained excellent health status as determined by physical examinations, hematology, and blood chemistry. While relative rates of body weight gain in restricted group 1 rhesus and squirrel monkeys have been markedly reduced, DR effects on crown-rump length (body height) have been variable. In addition, numerous physiological and biochemical parameters have been measured, and several exhibit significant cross-sectional age effects. Interestingly, several of these also exhibit possible species and genotype (group 1 and 2 rhesus) differences. A number of physiological parameters are emerging that might be altered by DR; however, further explanation of these effects awaits more extensive and detailed analyses.
ISSN:0077-8923
1749-6632
DOI:10.1111/j.1749-6632.1992.tb27434.x