Transcriptional Elongation by RNA Polymerase II and Histone Methylation

mRNA synthesis in eukaryotic organisms is a key biological process that is regulated at multiple levels. From the covalent modifications of chromatin by a number of chromatin remodeling complexes during the initiation and activation steps of transcription to the processing of mRNA transcripts, a ver...

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Bibliographic Details
Published in:The Journal of biological chemistry 2003-07, Vol.278 (29), p.26303-26306
Main Authors: Gerber, Mark, Shilatifard, Ali
Format: Article
Language:English
Subjects:
Animals
Histone Methyltransferases
Histone-Lysine N-Methyltransferase
Histones - chemistry
Histones - metabolism
Lysine - chemistry
Methylation
Methyltransferases - metabolism
Models, Biological
Protein Methyltransferases
RNA Polymerase II - metabolism
RNA, Messenger - biosynthesis
Transcription, Genetic
Transcriptional Elongation Factors - metabolism
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Summary:mRNA synthesis in eukaryotic organisms is a key biological process that is regulated at multiple levels. From the covalent modifications of chromatin by a number of chromatin remodeling complexes during the initiation and activation steps of transcription to the processing of mRNA transcripts, a very large consortium of proteins and multiprotein complexes is critical for gene expression by RNA polymerase II. The list of proteins essential for the successful synthesis of mRNA continues to grow at a rapid pace. Recent advances in this area of research have been focused on transcription through chromatin. In this article, we will review the recent literature linking the key biochemical process of transcriptional elongation by RNA polymerase II to histone methylation by COMPASS, Dot1p, and Set2 methyltransferases.
ISSN:0021-9258
1083-351X
DOI:10.1074/jbc.R300014200