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Short-Term Use of Estradiol for Depression in Perimenopausal and Postmenopausal Women: A Preliminary Report
OBJECTIVE: The authors examined the effect of a 4-week course of estrogen therapy on depression in perimenopausal and postmenopausal women. METHOD: Twenty-two depressed women who were either perimenopausal (N=10) or postmenopausal (N=12) received open-label treatment with transdermal 17 -estradiol (...
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| Published in: | The American journal of psychiatry 2003-08, Vol.160 (8), p.1519-1522 |
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| Main Authors: | , , , , , |
| Format: | Article |
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| container_end_page | 1522 |
| container_issue | 8 |
| container_start_page | 1519 |
| container_title | The American journal of psychiatry |
| container_volume | 160 |
| creator | Cohen, Lee S. Soares, Claudio N. Poitras, Jennifer R. Prouty, Jennifer Alexander, Allison B. Shifren, Jan L. |
| description | OBJECTIVE: The authors examined the effect of a 4-week course of estrogen therapy on depression in perimenopausal and postmenopausal women. METHOD: Twenty-two depressed women who were either perimenopausal (N=10) or postmenopausal (N=12) received open-label treatment with transdermal 17 -estradiol (100 g day) for 4 weeks. The Montgomery-Åsberg Depression Rating Scale and the Beck Depression Inventory were used to assess depressive symptoms, the Greene Climacteric Scale was used to assess menopause-related symptoms, and the Clinical Global Impression (CGI) was used to assess global clinical improvement in these women at baseline and after treatment. Remission of depression was defined as a score |
| doi_str_mv | 10.1176/appi.ajp.160.8.1519 |
| format | article |
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METHOD: Twenty-two depressed women who were either perimenopausal (N=10) or postmenopausal (N=12) received open-label treatment with transdermal 17 -estradiol (100 g day) for 4 weeks. The Montgomery-Åsberg Depression Rating Scale and the Beck Depression Inventory were used to assess depressive symptoms, the Greene Climacteric Scale was used to assess menopause-related symptoms, and the Clinical Global Impression (CGI) was used to assess global clinical improvement in these women at baseline and after treatment. Remission of depression was defined as a score <10 on the Montgomery-Åsberg Depression Rating Scale and a score ≤2 on the CGI at week 4. RESULTS: Remission of depression was noted in eight of the 20 women who completed the study; two of these women were postmenopausal, and six were perimenopausal. Antidepressant response was not associated with severity or subtypes of depression at study entry or with concomitant improvement in menopause-related symptoms. CONCLUSIONS: Some perimenopausal women with depression may benefit from short-term use of estrogen therapy, and its role for postmenopausal depressed women warrants further investigation. Antidepressant benefit associated with estrogen therapy may be independent of improvement in physical symptoms.</description><identifier>ISSN: 0002-953X</identifier><identifier>EISSN: 1535-7228</identifier><identifier>DOI: 10.1176/appi.ajp.160.8.1519</identifier><identifier>PMID: 12900318</identifier><identifier>CODEN: AJPSAO</identifier><language>eng</language><publisher>Washington, DC: American Psychiatric Publishing</publisher><subject>Administration, Cutaneous ; Adult ; Biological and medical sciences ; Climacteric - psychology ; Depressive Disorder - drug therapy ; Depressive Disorder - psychology ; Estradiol - administration & dosage ; Estradiol - therapeutic use ; Estrogen Replacement Therapy ; Estrogens ; Female ; Hormone replacement therapy ; Humans ; Medical sciences ; Menopause ; Mental depression ; Middle Aged ; Neuropharmacology ; Personality Inventory ; Pharmacology. Drug treatments ; Postmenopause - psychology ; Psychiatric Status Rating Scales ; Psychiatry ; Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease) ; Psychology. Psychoanalysis. Psychiatry ; Psychopharmacology ; Treatment Outcome ; Women</subject><ispartof>The American journal of psychiatry, 2003-08, Vol.160 (8), p.1519-1522</ispartof><rights>2004 INIST-CNRS</rights><rights>Copyright American Psychiatric Association Aug 2003</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a465t-9a602504455a3f7aa72cb100dd73abf5151a5f2bba0af90ca5101bf6ad2880c03</citedby><cites>FETCH-LOGICAL-a465t-9a602504455a3f7aa72cb100dd73abf5151a5f2bba0af90ca5101bf6ad2880c03</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://psychiatryonline.org/doi/epdf/10.1176/appi.ajp.160.8.1519$$EPDF$$P50$$Gappi$$H</linktopdf><linktohtml>$$Uhttps://psychiatryonline.org/doi/full/10.1176/appi.ajp.160.8.1519$$EHTML$$P50$$Gappi$$H</linktohtml><link.rule.ids>314,780,784,2855,21626,21627,21628,27924,27925,77794,77799</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15045497$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12900318$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cohen, Lee S.</creatorcontrib><creatorcontrib>Soares, Claudio N.</creatorcontrib><creatorcontrib>Poitras, Jennifer R.</creatorcontrib><creatorcontrib>Prouty, Jennifer</creatorcontrib><creatorcontrib>Alexander, Allison B.</creatorcontrib><creatorcontrib>Shifren, Jan L.</creatorcontrib><title>Short-Term Use of Estradiol for Depression in Perimenopausal and Postmenopausal Women: A Preliminary Report</title><title>The American journal of psychiatry</title><addtitle>Am J Psychiatry</addtitle><description>OBJECTIVE: The authors examined the effect of a 4-week course of estrogen therapy on depression in perimenopausal and postmenopausal women. METHOD: Twenty-two depressed women who were either perimenopausal (N=10) or postmenopausal (N=12) received open-label treatment with transdermal 17 -estradiol (100 g day) for 4 weeks. The Montgomery-Åsberg Depression Rating Scale and the Beck Depression Inventory were used to assess depressive symptoms, the Greene Climacteric Scale was used to assess menopause-related symptoms, and the Clinical Global Impression (CGI) was used to assess global clinical improvement in these women at baseline and after treatment. Remission of depression was defined as a score <10 on the Montgomery-Åsberg Depression Rating Scale and a score ≤2 on the CGI at week 4. RESULTS: Remission of depression was noted in eight of the 20 women who completed the study; two of these women were postmenopausal, and six were perimenopausal. Antidepressant response was not associated with severity or subtypes of depression at study entry or with concomitant improvement in menopause-related symptoms. CONCLUSIONS: Some perimenopausal women with depression may benefit from short-term use of estrogen therapy, and its role for postmenopausal depressed women warrants further investigation. Antidepressant benefit associated with estrogen therapy may be independent of improvement in physical symptoms.</description><subject>Administration, Cutaneous</subject><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Climacteric - psychology</subject><subject>Depressive Disorder - drug therapy</subject><subject>Depressive Disorder - psychology</subject><subject>Estradiol - administration & dosage</subject><subject>Estradiol - therapeutic use</subject><subject>Estrogen Replacement Therapy</subject><subject>Estrogens</subject><subject>Female</subject><subject>Hormone replacement therapy</subject><subject>Humans</subject><subject>Medical sciences</subject><subject>Menopause</subject><subject>Mental depression</subject><subject>Middle Aged</subject><subject>Neuropharmacology</subject><subject>Personality Inventory</subject><subject>Pharmacology. Drug treatments</subject><subject>Postmenopause - psychology</subject><subject>Psychiatric Status Rating Scales</subject><subject>Psychiatry</subject><subject>Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease)</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychopharmacology</subject><subject>Treatment Outcome</subject><subject>Women</subject><issn>0002-953X</issn><issn>1535-7228</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><recordid>eNp9kU1r3DAQhkVpabZJfkGhiEJ7szOSLMvuLSTpBwSy5IP0Jsa2RLW1LVeyD_n30XaXJvSQkzTDM_POzEvIewY5Y6o8wWlyOW6mnJWQVzmTrH5FVkwKmSnOq9dkBQA8q6X4eUDexbhJIQjF35IDxuv0ZdWK_L755cOc3Zow0LtoqLf0Is4BO-d7an2g52YKJkbnR-pGujbBDWb0Ey4Re4pjR9c-zs9S9z4FX-gpXQfTu8GNGB7otZmSyhF5Y7GP5nj_HpK7rxe3Z9-zy6tvP85OLzMsSjlnNZbAJRSFlCisQlS8bRhA1ymBjZVpUZSWNw0C2hpalAxYY0vseFVBC-KQfN71nYL_s5g468HF1vQ9jsYvUStRKFErnsCP_4Ebv4QxzaY5h6ISJS8TJHZQG3yMwVg9pRukrTQDvTVCb43QyQidjNCV3hqRqj7sWy_NYLqnmv3lE_BpD2BssbcBx9bFJy4dQBa1ShzsuL8q_-Z7SfsRDkejUA</recordid><startdate>20030801</startdate><enddate>20030801</enddate><creator>Cohen, Lee S.</creator><creator>Soares, Claudio N.</creator><creator>Poitras, Jennifer R.</creator><creator>Prouty, Jennifer</creator><creator>Alexander, Allison B.</creator><creator>Shifren, Jan L.</creator><general>American Psychiatric Publishing</general><general>American Psychiatric Association</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope></search><sort><creationdate>20030801</creationdate><title>Short-Term Use of Estradiol for Depression in Perimenopausal and Postmenopausal Women: A Preliminary Report</title><author>Cohen, Lee S. ; Soares, Claudio N. ; Poitras, Jennifer R. ; Prouty, Jennifer ; Alexander, Allison B. ; Shifren, Jan L.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a465t-9a602504455a3f7aa72cb100dd73abf5151a5f2bba0af90ca5101bf6ad2880c03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Administration, Cutaneous</topic><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Climacteric - psychology</topic><topic>Depressive Disorder - drug therapy</topic><topic>Depressive Disorder - psychology</topic><topic>Estradiol - administration & dosage</topic><topic>Estradiol - therapeutic use</topic><topic>Estrogen Replacement Therapy</topic><topic>Estrogens</topic><topic>Female</topic><topic>Hormone replacement therapy</topic><topic>Humans</topic><topic>Medical sciences</topic><topic>Menopause</topic><topic>Mental depression</topic><topic>Middle Aged</topic><topic>Neuropharmacology</topic><topic>Personality Inventory</topic><topic>Pharmacology. Drug treatments</topic><topic>Postmenopause - psychology</topic><topic>Psychiatric Status Rating Scales</topic><topic>Psychiatry</topic><topic>Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease)</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychopharmacology</topic><topic>Treatment Outcome</topic><topic>Women</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cohen, Lee S.</creatorcontrib><creatorcontrib>Soares, Claudio N.</creatorcontrib><creatorcontrib>Poitras, Jennifer R.</creatorcontrib><creatorcontrib>Prouty, Jennifer</creatorcontrib><creatorcontrib>Alexander, Allison B.</creatorcontrib><creatorcontrib>Shifren, Jan L.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>The American journal of psychiatry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cohen, Lee S.</au><au>Soares, Claudio N.</au><au>Poitras, Jennifer R.</au><au>Prouty, Jennifer</au><au>Alexander, Allison B.</au><au>Shifren, Jan L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Short-Term Use of Estradiol for Depression in Perimenopausal and Postmenopausal Women: A Preliminary Report</atitle><jtitle>The American journal of psychiatry</jtitle><addtitle>Am J Psychiatry</addtitle><date>2003-08-01</date><risdate>2003</risdate><volume>160</volume><issue>8</issue><spage>1519</spage><epage>1522</epage><pages>1519-1522</pages><issn>0002-953X</issn><eissn>1535-7228</eissn><coden>AJPSAO</coden><abstract>OBJECTIVE: The authors examined the effect of a 4-week course of estrogen therapy on depression in perimenopausal and postmenopausal women. METHOD: Twenty-two depressed women who were either perimenopausal (N=10) or postmenopausal (N=12) received open-label treatment with transdermal 17 -estradiol (100 g day) for 4 weeks. The Montgomery-Åsberg Depression Rating Scale and the Beck Depression Inventory were used to assess depressive symptoms, the Greene Climacteric Scale was used to assess menopause-related symptoms, and the Clinical Global Impression (CGI) was used to assess global clinical improvement in these women at baseline and after treatment. Remission of depression was defined as a score <10 on the Montgomery-Åsberg Depression Rating Scale and a score ≤2 on the CGI at week 4. RESULTS: Remission of depression was noted in eight of the 20 women who completed the study; two of these women were postmenopausal, and six were perimenopausal. Antidepressant response was not associated with severity or subtypes of depression at study entry or with concomitant improvement in menopause-related symptoms. CONCLUSIONS: Some perimenopausal women with depression may benefit from short-term use of estrogen therapy, and its role for postmenopausal depressed women warrants further investigation. Antidepressant benefit associated with estrogen therapy may be independent of improvement in physical symptoms.</abstract><cop>Washington, DC</cop><pub>American Psychiatric Publishing</pub><pmid>12900318</pmid><doi>10.1176/appi.ajp.160.8.1519</doi><tpages>4</tpages></addata></record> |
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| identifier | ISSN: 0002-953X |
| ispartof | The American journal of psychiatry, 2003-08, Vol.160 (8), p.1519-1522 |
| issn | 0002-953X 1535-7228 |
| language | eng |
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| source | PsychiatryOnline |
| subjects | Administration, Cutaneous Adult Biological and medical sciences Climacteric - psychology Depressive Disorder - drug therapy Depressive Disorder - psychology Estradiol - administration & dosage Estradiol - therapeutic use Estrogen Replacement Therapy Estrogens Female Hormone replacement therapy Humans Medical sciences Menopause Mental depression Middle Aged Neuropharmacology Personality Inventory Pharmacology. Drug treatments Postmenopause - psychology Psychiatric Status Rating Scales Psychiatry Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease) Psychology. Psychoanalysis. Psychiatry Psychopharmacology Treatment Outcome Women |
| title | Short-Term Use of Estradiol for Depression in Perimenopausal and Postmenopausal Women: A Preliminary Report |
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