The nucleus raphe magnus modulates hypoxia-induced hyperventilation but not anapyrexia in rats

The nucleus raphe magnus (NRM) is one of the brainstem cell groups involved in physiological responses to hypoxia. Thus, we tested the hypothesis that the NRM modulates hypoxia-induced hyperventilation and anapyrexia. To this end, we assessed the participation of NRM in the respiratory and thermoreg...

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Bibliographic Details
Published in:Neuroscience letters 2003-08, Vol.347 (2), p.121-125
Main Authors: Gargaglioni, Luciane H, Coimbra, Norberto C, Branco, Luiz G.S
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Body temperature
Body Temperature Regulation
Central nervous system
Fever - etiology
Fever - physiopathology
Fundamental and applied biological sciences. Psychology
Hyperventilation - etiology
Hyperventilation - physiopathology
Hypothermia
Hypoxia - complications
Ibotenic acid
Male
Motor control and motor pathways. Reflexes. Control centers of vegetative functions. Vestibular system and equilibration
Oxygen
Raphe Nuclei - physiopathology
Rats
Rats, Wistar
Ventilation
Vertebrates: nervous system and sense organs
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Summary:The nucleus raphe magnus (NRM) is one of the brainstem cell groups involved in physiological responses to hypoxia. Thus, we tested the hypothesis that the NRM modulates hypoxia-induced hyperventilation and anapyrexia. To this end, we assessed the participation of NRM in the respiratory and thermoregulatory responses to hypoxia using ibotenic acid lesions produced in the NRM of rats. Our results demonstrated that, under resting breathing, NRM plays no role in ventilation or body temperature. Hypoxia caused hyperventilation and anapyrexia in all groups. NMR lesions elicited an increased ventilatory response to hypoxia due to a higher tidal volume ( V T) but did not affect hypoxia-induced anapyrexia . Therefore, we conclude that NRM exerts an inhibitory modulation of breathing during hypoxia, acting on V T, but plays no role in the hypoxia-induced anapyrexia.
ISSN:0304-3940
1872-7972
DOI:10.1016/S0304-3940(03)00671-2