Event-related fMRI for the suppression of speech-associated artifacts in stuttering

• Published in: NeuroImage (Orlando, Fla.) Fla.), 2003-07, Vol.19 (3), p.1076-1084
• Main Authors: Preibisch, Christine, Raab, Peter, Neumann, Katrin, Euler, Harald A, von Gudenberg, Alexander W, Gall, Volker, Lanfermann, Heinrich, Zanella, Friedhelm
• Format: Article
• Language: English
• Subjects: Adult; Brain; Cerebral Cortex - anatomy & histology; Cerebral Cortex - physiology; Computer Simulation; Evoked Potentials - physiology; Female; Humans; Image Processing, Computer-Assisted; Magnetic fields; Magnetic Resonance Imaging; Male; Middle Aged; Models, Statistical; Psychomotor Performance - physiology; Reading; Software; Speech; Speech - physiology; Studies; Stuttering - physiopathology; Time series
• ISSN: 1053-8119; 1095-9572
• DOI: 10.1016/S1053-8119(03)00157-5

The purpose of this study was to establish functional magnetic resonance imaging (fMRI) for the investigation of brain function during overt speech production in stuttering. Up to now this technique has rarely been used for the investigation of speech production paradigms because artifacts related to overt speaking largely impair the sensitivity toward task-related activation. Recently, the temporal delay of the hemodynamic response has been exploited to achieve a suppression of speech-related artifacts. By the limitation to very short utterances (one word), a temporal segregation of the respective effects was accomplished by means of an event-related experimental design. However, the investigation of speech production in persons who stutter requires a more extensive speaking situation. Since longer and more complex utterances evoke more symptoms of stuttering than reading of single words, a useful task should at least include the reading of full sentences. In this study we performed simulations to investigate the correlation of speech-related artifacts with the respective hemodynamic response in dependency on speech duration and rate of data sampling. Furthermore, we show that prolonged stimulus durations and repetition times of 3 s still allow an effective suppression of speech-related artifacts in fluent as well as in nonfluent speakers. Not only were obvious false activations at high contrast cerebrospinal fluid tissue borders widely eliminated, subjects also displayed consistent activation in speech-related and motor areas. As these results widely resemble those obtained by earlier neuroimaging studies on language production, event-related fMRI seems to be capable of recording neurophysiological correlates of overt speech production.