Analysis of anti-HBs levels in healthcare workers over 10 years following booster vaccination for hepatitis B virus

In this study, we analyzed anti-HBs levels in 104 Japanese healthcare workers who received three booster HBV surface antigen (HBsAg) vaccines because 80 became anti-HBs-negative at a mean of 2.4 years after the primary vaccination and 24 did not respond to primary vaccination. Of the re-vaccinees, 9...

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Bibliographic Details
Published in:Vaccine 2003-09, Vol.21 (25-26), p.3789-3794
Main Authors: Nakao, Kazuhiko, Hamasaki, Keisuke, Wakihama, Naoko, Maeda, Mayumi, Ohtsubo, Noriko, Sagiike, Tomiko, Ichikawa, Tatsuki, Ishikawa, Hiroki, Eguchi, Katsumi, Ishii, Nobuko
Format: Article
Language:English
Subjects:
Adult
Anti-HBs
Booster vaccination
Enzymes
Female
Health care
Health Personnel
Healthcare worker
Hepatitis
Hepatitis Antibodies - blood
Hepatitis B
Hepatitis B surface antigen
Hepatitis B Surface Antigens - analysis
Hepatitis B Surface Antigens - immunology
Hepatitis B Vaccines - immunology
Hepatitis B virus
Humans
Immunization
Immunization, Secondary
Immunogenicity
Immunology
Infections
Japan
Male
Medical personnel
Middle Aged
Time Factors
Vaccines
Vaccines, Synthetic - immunology
Viruses
Workers
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Summary:In this study, we analyzed anti-HBs levels in 104 Japanese healthcare workers who received three booster HBV surface antigen (HBsAg) vaccines because 80 became anti-HBs-negative at a mean of 2.4 years after the primary vaccination and 24 did not respond to primary vaccination. Of the re-vaccinees, 96% achieved a level of 10mIU/ml or more of anti-HBs (i.e. seroprotected), 1 month after booster vaccination. Although anti-HBs levels of re-vaccinees decreased as rapidly as those of primary immunized vaccinees, at 10 years post-booster, 64% of re-vaccinees maintained anti-HBs levels at 10mIU/ml or higher. Our results suggest that the additional three-dose protocol of booster HBsAg vaccination is beneficial in maintaining a seroprotective level of anti-HBs until new immunogenic vaccination protocols are established.
ISSN:0264-410X
1873-2518
DOI:10.1016/S0264-410X(03)00313-X