Levels of Interleukin-15 in Plasma May Predict a Favorable Outcome of Structured Treatment Interruption in Patients with Chronic Human Immunodeficiency Virus Infection

Structured treatment interruption (STI) may help to alleviate the problems associated with long-term antiretroviral therapy (ART) in human immunodeficiency virus (HIV)–infected patients. We analyzed the role that baseline levels of cytokines in plasma play as markers of a favorable outcome of STI. T...

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Bibliographic Details
Published in:The Journal of infectious diseases 2003-09, Vol.188 (5), p.661-665
Main Authors: Amicosante, Massimo, Poccia, Fabrizio, Gioia, Cristiana, Montesano, Carla, Topino, Simone, Martini, Federico, Narciso, Pasquale, Pucillo, Leopoldo P., D’Offizi, Gianpiero
Format: Article
Language:English
Subjects:
Adult
Anti-HIV Agents - administration & dosage
Anti-HIV Agents - therapeutic use
Biological and medical sciences
Chronic Disease
Cytokines
Drug Administration Schedule
Female
HIV
HIV 1
HIV infections
HIV Infections - drug therapy
HIV Infections - immunology
HIV Infections - virology
HIV-1 - drug effects
HIV/Aids
Human viral diseases
Humans
Infections
Infectious diseases
Interleukin-15 - blood
Male
Medical sciences
Middle Aged
Predictive Value of Tests
T lymphocytes
Transponders
Treatment Outcome
Tumor Necrosis Factor-alpha - metabolism
Viral diseases
Viral diseases of the lymphoid tissue and the blood. Aids
Viral morphology
Viremia
Viremia - drug therapy
Viremia - immunology
Viremia - virology
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Summary:Structured treatment interruption (STI) may help to alleviate the problems associated with long-term antiretroviral therapy (ART) in human immunodeficiency virus (HIV)–infected patients. We analyzed the role that baseline levels of cytokines in plasma play as markers of a favorable outcome of STI. Two groups of patients were defined: STI responders and STI nonresponders. STI responders showed a higher baseline concentration of interleukin (IL)–15 in plasma than did STI nonresponders and showed lower levels of tumor necrosis factor (TNF)–α during STI. No differences were observed in levels of IL-2, IL-7, or interferon-α in plasma. Our data show that (1) levels of TNF-α in plasma correlate with HIV viremia and (2) monitoring baseline levels of IL-15 in plasma allows for the identification of a favorable outcome of STI
ISSN:0022-1899
1537-6613
DOI:10.1086/377454