High-pressure liquid chromatographic assay of theophylline, ephedrine hydrochloride, and phenobarbital tablets

An innovative high-pressure liquid chromatographic method is described in which theophylline, ephedrine hydrochloride (measured as benzaldehyde), and phenobarbital are determined simultaneously with butabarbital as the internal standard. Chromatographic conditions were selected to afford a pH suffic...

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Bibliographic Details
Published in:Journal of pharmaceutical sciences 1981-07, Vol.70 (7), p.804-806
Main Authors: Chen, Tsun-Ming, Chafetz, Lester
Format: Article
Language:English
Subjects:
and phenobarbital
Chromatography, High Pressure Liquid - methods
conventional and sustained-action tablet formulations
Delayed-Action Preparations - analysis
Drug Combinations - analysis
Ephedrine - analysis
ephedrine hydrochloride
Ephedrine hydrochloride-simultaneous determination with theophylline and phenobarbital by high-pressure liquid chromatography
Ephedrine hydrochloride—simultaneous determination with theophylline and phenobarbital by high-pressure liquid chromatography, conventional and sustained-action tablet formulations
High-pressure liquid chromatography-simultaneous determination of theophylline
High-pressure liquid chromatography—simultaneous determination of theophylline, ephedrine hydrochloride, and phenobarbital, conventional and sustained-action tablet formulations
Phenobarbital - analysis
Phenobarbital-simultaneous determination with theophylline and ephedrine hydrochloride by high-pressure liquid chromatography
Phenobarbital—simultaneous determination with theophylline and ephedrine hydrochloride by high-pressure liquid chromatography, conventional and sustained-action tablet formulations
Tablets - analysis
Theophylline - analysis
Theophylline-simultaneous determination with ephedrine hydrochloride and phenobarbital by high-pressure liquid chromatography
Theophylline—simultaneous determination with ephedrine hydrochloride and phenobarbital by high-pressure liquid chromatography, conventional and sustained-action tablet formulations
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Description
Summary:An innovative high-pressure liquid chromatographic method is described in which theophylline, ephedrine hydrochloride (measured as benzaldehyde), and phenobarbital are determined simultaneously with butabarbital as the internal standard. Chromatographic conditions were selected to afford a pH sufficient for rapid oxidation of ephedrine and relatively high UV absorbance for the barbiturates and a detection wavelength near the maximum for benzaldehyde and the barbiturates and the minimum for theophylline. Chromatograms show peaks from iodate, theophylline, phenobarbital, butabarbital, and benzaldehyde, in order of increasing retention time, all within the dynamic range of a conventional recorder. Procedures are provided for the assay of conventional and sustained-action tablet formulations.
ISSN:0022-3549
1520-6017
DOI:10.1002/jps.2600700726