Effects of Infection with Influenza Virus on the Function of Polymorphonuclear Leukocytes

Five studies of the function of polymorphonuclear leukocytes (PMNLs) from peripheral blood were performed during 1971-1977 on volunteers who were inoculated intranasally with influenza A virus (H3N2), to which they had negligible antibody. Subjects who resisted infection had higher total leukocyte a...

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Bibliographic Details
Published in:The Journal of infectious diseases 1981-09, Vol.144 (3), p.279-279
Main Authors: Martin, R. Russell, Couch, Robert B., Greenberg, Stephen B., Cate, Thomas R., Warr, Glenn A.
Format: Article
Language:English
Subjects:
Antibodies, Viral
Chemotaxis
Chemotaxis, Leukocyte
Data Forum
H3N2 subtype influenza A virus
Humans
Infections
Influenza A virus
Influenza A virus - immunology
Influenza, Human - immunology
Inoculation
Leukocytes
Neutrophils
Neutrophils - immunology
Orthomyxoviridae
Phagocytosis
Volunteerism
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Summary:Five studies of the function of polymorphonuclear leukocytes (PMNLs) from peripheral blood were performed during 1971-1977 on volunteers who were inoculated intranasally with influenza A virus (H3N2), to which they had negligible antibody. Subjects who resisted infection had higher total leukocyte and PMNL counts and greater PMNL phagocytosis of staphylococci than those who became infected. After inoculation, leukocyte counts increased in both groups of volunteers. PMNL chemotaxis to casein hydrolysate and to influenza A virus (H3H2) decreased significantly during racovery only for the group of infected volunteers. Results of leukocyte testing for infected volunteers with and without illness were similar. The association of increased numbers and activity of PMNLs with resistance to infection with influenza virus is unexplained. However, except for delayed impairment of chemotaxis, no consistent abnormality in PMNL function that might predispose the host to bacterial superinfection was found during mild influenza.
ISSN:0022-1899
1537-6613
DOI:10.1093/infdis/144.3.279