Anti-endothelial cell autoantibodies and soluble markers of endothelial cell dysfunction in systemic lupus erythematosus

OBJECTIVE: To determine if anti-endothelial cell antibodies (AECA) and plasma markers of endothelial cell function are related to disease severity in systemic lupus erythematosus (SLE). METHODS: We measured AECA by human umbilical vein endothelial cell binding, endothelial markers von Willebrand fac...

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Published in:Journal of rheumatology 2003-09, Vol.30 (9), p.1963-1966
Main Authors: CONSTANS, Joel, DUPUY, Remy, CONRI, Claude, BLANN, Andrew D, RESPLANDY, Francois, SEIGNEUR, Martine, RENARD, Martine, LONGY-BOURSIER, Maite, SCHAEVERBEKE, Thierry, GUERIN, Viviane, BOISSEAU, Michel R
Format: Article
Language:English
Subjects:
Adult
Antibodies, Antinuclear - analysis
Antibodies, Antinuclear - immunology
Autoantibodies - analysis
Autoantibodies - immunology
Biological and medical sciences
Biomarkers - analysis
Case-Control Studies
Cohort Studies
Disease Progression
E-Selectin - analysis
E-Selectin - immunology
Endothelial Cells - immunology
Endothelial Cells - pathology
Enzyme-Linked Immunosorbent Assay
Female
Humans
Lupus Erythematosus, Systemic - diagnosis
Lupus Erythematosus, Systemic - immunology
Male
Medical sciences
Middle Aged
Prognosis
Reference Values
Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis
Sensitivity and Specificity
Severity of Illness Index
Solubility
Statistics, Nonparametric
Thrombomodulin - analysis
Thrombomodulin - immunology
von Willebrand Factor - analysis
von Willebrand Factor - immunology
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Summary:OBJECTIVE: To determine if anti-endothelial cell antibodies (AECA) and plasma markers of endothelial cell function are related to disease severity in systemic lupus erythematosus (SLE). METHODS: We measured AECA by human umbilical vein endothelial cell binding, endothelial markers von Willebrand factor, soluble thrombomodulin, and soluble E-selectin by ELISA, and disease severity by SLEDAI and SLICC/ACR in 35 patients with SLE. RESULTS: Despite high levels of IgG AECA (p = 0.001) and von Willebrand factor (p = 0.0007) compared to 21 healthy controls, we found a positive correlation only between IgG AECA and the SLEDAI index (r = 0.393, p = 0.021). CONCLUSION: IgG AECA seem to be related to disease activity in SLE, possibly in a pathogenic role. Conversely, plasma markers of endothelial cell damage seem to be an epiphenomenon and may simply be related to excess inflammation.
ISSN:0315-162X
1499-2752