Induction of hepatic granulopoiesis due to chorioamnionitis during the second trimester of development

Objective: To detect post mortem changes in fetal hematopoiesis consistent with infection from liver examination alone. Study design: We investigated the immunohistochemical expression of Glycophorin C, Neutrophilic elastase, and CD34, in the hepatic parenchyma from fetuses miscarried as a result of...

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Bibliographic Details
Published in:European journal of obstetrics & gynecology and reproductive biology 2003-10, Vol.110 (2), p.164-168
Main Authors: Tamiolakis, D., Kotini, A., Jivannakis, T., Papadopoulos, N.
Format: Article
Language:English
Subjects:
Abortion, Spontaneous - microbiology
Antigens, CD34 - analysis
Bacterial diseases
Bacterial diseases of the genital system
Biological and medical sciences
Chlamydia Infections
Chlamydia trachomatis
Chorioamnionitis
Chorioamnionitis - complications
Chorioamnionitis - diagnosis
Chorioamnionitis - pathology
Diseases of mother, fetus and pregnancy
Female
Gestational Age
Granulocytes
Gynecology. Andrology. Obstetrics
Hematopoiesis, Extramedullary
Human bacterial diseases
Humans
Immunohistochemistry
Infectious diseases
Liver - embryology
Liver - pathology
Liver hematopoiesis
Medical sciences
Pregnancy
Pregnancy Complications, Infectious - microbiology
Pregnancy. Fetus. Placenta
Second trimester of gestation
Spontaneous abortion
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Summary:Objective: To detect post mortem changes in fetal hematopoiesis consistent with infection from liver examination alone. Study design: We investigated the immunohistochemical expression of Glycophorin C, Neutrophilic elastase, and CD34, in the hepatic parenchyma from fetuses miscarried as a result of chorioamnionitis (caused by Chlamydia trachomatis) and correlated them with the equivalent from fetuses after voluntary abortion (gestational age: 16th, 20th, and 24th weeks). Results: A statistically significant difference was found in the Neutrophilic elastase positive cells to the advantage of cases with chorioamnionitis over voluntary abortions (24th week: P=0.0001, t-test) and also at the level of total hematopoiesis (20th and 24th week: P=0.041 and 0.004, respectively, t-test). There was no quantitative difference between the two settings at the level of erythropoiesis in the three examined periods. Conclusions: Fetal infection can be diagnosed from the liver alone. After detection of changes in fetal hematopoiesis indicative of infection, examination of additional specimens of placenta and membranes will document the diagnosis of chorioamnionitis.
ISSN:0301-2115
1872-7654
DOI:10.1016/S0301-2115(03)00114-3