Association Study of Polymorphisms in the Human Estrogen Receptor Alpha Gene and Prostate Cancer Risk

Objectives: Prostate cancer is a very common hormone-related malignancy in Western countries. It is initially dependent on androgen stimulation but in vitro growth of prostate cancer cells are also dependent on estrogen. Our goal was to elucidate if some polymorphisms of estrogen receptor alpha gene...

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Bibliographic Details
Published in:European urology 2003-10, Vol.44 (4), p.487-490
Main Authors: Cancel-Tassin, Géraldine, Latil, Alain, Rousseau, Francis, Mangin, Philippe, Bottius, Emmanuel, Escary, Jean-Louis, Berthon, Philippe, Cussenot, Olivier
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Biological and medical sciences
Estrogen Receptor alpha
Estrogen receptor alpha gene
Humans
Male
Medical sciences
Middle Aged
Nephrology. Urinary tract diseases
Polymorphism
Polymorphism, Genetic
Prostate cancer
Prostatic Neoplasms - epidemiology
Prostatic Neoplasms - genetics
Receptors, Estrogen - genetics
Risk Factors
Tumors of the urinary system
Urinary tract. Prostate gland
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Summary:Objectives: Prostate cancer is a very common hormone-related malignancy in Western countries. It is initially dependent on androgen stimulation but in vitro growth of prostate cancer cells are also dependent on estrogen. Our goal was to elucidate if some polymorphisms of estrogen receptor alpha gene might be associated with the risk of prostate cancer. Methods: Using DHPLC techniques, each coding exon of the estrogen receptor alpha gene was screened for new polymorphisms in germline DNA from 96 healthy controls and 96 sporadic prostate cancer cases. Identified polymorphisms were then genotyped and their distribution compared between the two populations. Results: Thirteen polymorphisms were identified. A difference was found in the distribution of one newly identified polymorphism, namely a GGGA repeat located in the first intron of the gene. The common wild type genotype consisted of two alleles with five GGGA repetitions (5/5 genotype). Indeed this 5/5 genotype was found in 294/296 controls (99.3%) and 285/294 patients (96.9%; OR, 4.6; 95% CI, 0.99–21.67). Among the nine patients with a different genotype, one was 4/5, seven were 5/6 and one was 6/6. Conclusion: These results suggest that variants of the GGGA polymorphism from the estrogen receptor alpha gene may be associated with an increased risk of developing prostate cancer.
ISSN:0302-2838
1873-7560
DOI:10.1016/S0302-2838(03)00319-1