Abdominal Vagotomy Blocks the Satiety Effect of Cholecystokinin in the Rat

The site where peripherally administered cholecystokinin-8 elicits satiety was investigated by injecting rats with cholecystokinin-8 (1 to 8 micrograms per kilogram of body weight, intraperitoneally) after they had received bilateral lesions of the ventromedial hypothalamus or after they had undergo...

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Bibliographic Details
Published in:Science (American Association for the Advancement of Science) 1981-08, Vol.213 (4511), p.1036-1037
Main Authors: Smith, G. P., Jerome, C., Cushin, B. J., Eterno, R., Simansky, K. J.
Format: Article
Language:English
Subjects:
Abdomen
Afferent Pathways
Analysis of variance
Animals
Appetite
Appetite (Psychophysiology)
Atropine
Brain - physiology
Cholecystokinin - pharmacology
Efferent Pathways
Food intake
Lesions
Nitrates
Peptide hormones
Physiological aspects
Rats
Satiation - drug effects
Satiety
Stomach - innervation
Tree trunks
Vagotomy
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Summary:The site where peripherally administered cholecystokinin-8 elicits satiety was investigated by injecting rats with cholecystokinin-8 (1 to 8 micrograms per kilogram of body weight, intraperitoneally) after they had received bilateral lesions of the ventromedial hypothalamus or after they had undergone bilateral abdominal vagotomy or selective vagotomies. Abdominal vagotomy or gastric vagotomy abolished or reduced the satiety effect of cholecystokinin, but lesions of the ventromedial hypothalamus did not. These results demonstrate that peripherally administered cholecystokinin acts in the abdomen through gastric vagal fibers and not directly on the brain to produce satiety in the rat.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.7268408