The effect of elevated outflow pressure on flow resistance and the transfer of THO, albumin and glucose in the isolated guinea pig placenta

In the isolated, artificially perfused guinea pig placenta the relationship between arterial pressures, venous pressures and the relative transfer of 3H2O, D-glucose and albumin was studied at constant arterial perfusion rates. The results were as follows: A. Elevation of the fetal venous pressure i...

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Bibliographic Details
Published in:Pflügers Archiv 1977-11, Vol.371 (3), p.251-256
Main Authors: Leichtweiss, H P, Schröder, H
Format: Article
Language:English
Subjects:
Animals
Blood Glucose - metabolism
Blood Pressure
Female
Filtration
Guinea Pigs
Hydrostatic Pressure
Maternal-Fetal Exchange
Perfusion
Placenta - blood supply
Placenta - physiology
Pregnancy
Serum Albumin - metabolism
Umbilical Arteries
Umbilical Veins
Uterus - blood supply
Vascular Resistance
Venous Pressure
Water - metabolism
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Summary:In the isolated, artificially perfused guinea pig placenta the relationship between arterial pressures, venous pressures and the relative transfer of 3H2O, D-glucose and albumin was studied at constant arterial perfusion rates. The results were as follows: A. Elevation of the fetal venous pressure induces an increase of flow resistance at the maternal side. Fetal perfusion resistance is raised by elevated pressure in the uterine vein also, the effect is much more pronounced, however. B. When the outflow resistance increases, a net transfer of water especially from the fetal to the maternal side can be observed. The relationship between the venous pressure difference and the rate of filtration is non-linear. C. The fetomaternal transfer of 131J-albumin and of 3H2O resp. D-glucose is influenced by fetomaternal filtration to a different degree. Whereas the albumin transfer increases strongly, the transfer rates of tritiated water and glucose change little.
ISSN:0031-6768
1432-2013
DOI:10.1007/BF00586265