Studies of Inactivated Influenza Virus Vaccines in Hospital Employees: Reactogenicity and Absenteeism

The impact of a mass influenza vaccination program on the operation of a major medical center was evaluated in adult volunteer employees who were given either ether-split or whole-virus bivalent influenza vaccine in a double-blind manner by jet-injector gun. Each volunteer completed a reaction infor...

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Bibliographic Details
Published in:The Journal of infectious diseases 1977-12, Vol.136 (Supplement-3), p.S533-S538
Main Authors: Mostow, Steven R., Eickhoff, Theodore C., Chelgren, Gladys A., Retailliau, Henry F., Castle, Mary
Format: Article
Language:English
Subjects:
Absenteeism
Adult
C. Bivalent Vaccines in Adults
Clinical Trials as Topic
Double-Blind Method
Female
Fever
Hospital administration
Human resources
Humans
Influenza A virus - immunology
Influenza Vaccines - adverse effects
Influenza Vaccines - pharmacology
Male
Medical syringes
Medication administration
Middle Aged
Orthomyxoviridae
Personnel, Hospital
Vaccination
Viruses
Volunteerism
Workplace absenteeism
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Summary:The impact of a mass influenza vaccination program on the operation of a major medical center was evaluated in adult volunteer employees who were given either ether-split or whole-virus bivalent influenza vaccine in a double-blind manner by jet-injector gun. Each volunteer completed a reaction information form, nurses monitored temperatures, and data on absenteeism of the employees of the Nursing Service and the Building Management Service were collected. The results of this study demonstrated that the mass campaign did not adversely affect absenteeism. However, the whole-virus vaccine caused significantly more local, systemic, and febrile reactions than the split-virus vaccine. Purified inactivated influenza virus vaccines can be given in a mass campaign to hospital personnel without adversely affecting the operation of the hospital.
ISSN:0022-1899
1537-6613
DOI:10.1093/infdis/136.Supplement_3.S533