Apathy, Depression, and Cognitive Performance in HIV-1 Infection

The authors examined the relationship between apathy, depression, and cognitive performance in 48 HIV-1-seropositive and 21 seronegative (control) subjects, using reaction time (RT) and working memory tasks. Apathy, but not depression, was associated with working memory deficits among HIV-seropositi...

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Bibliographic Details
Published in:The journal of neuropsychiatry and clinical neurosciences 1998, Vol.10 (3), p.320-329
Main Authors: Castellon, Steven A, Hinkin, Charles H, Wood, Stacey, Yarema, Kathryn T
Format: Article
Language:English
Subjects:
Adult
AIDS Dementia Complex - diagnosis
AIDS Dementia Complex - psychology
AIDS/HIV
Cognition Disorders - diagnosis
Cognition Disorders - psychology
Depressive Disorder - diagnosis
Depressive Disorder - psychology
Diagnosis, Differential
HIV Seropositivity - diagnosis
HIV Seropositivity - psychology
HIV-1
Humans
Male
Mental Recall
Middle Aged
Neuropsychological Tests
Personality Inventory
Reaction Time
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Summary:The authors examined the relationship between apathy, depression, and cognitive performance in 48 HIV-1-seropositive and 21 seronegative (control) subjects, using reaction time (RT) and working memory tasks. Apathy, but not depression, was associated with working memory deficits among HIV-seropositive subjects. The cognitive-affective component of the Beck Depression Inventory (BDI), but not apathy, was associated with slowing and decreased accuracy on a choice RT task. The BDI cognitive-affective component was more closely associated than the BDI somatic component with both RT slowing and apathy. Results suggest that prominent symptoms of apathy, independent of depression, may be an important indicator of CNS involvement in HIV infection. Total BDI scores showed a less consistent relationship with neurocognitive performance, suggesting that somatic symptomatology is diagnostically ambiguous among HIV-infected subjects.
ISSN:0895-0172
1545-7222
DOI:10.1176/jnp.10.3.320