Response programming in patients with schizophrenia: A kinematic analysis

Schizophrenia may involve disturbed subcortical mechanisms or anomalous functional asymmetries. We therefore examined any anomalies of functional asymmetry in a kinematic analysis of a cued sequential movement task previously found to be sensitive to basal ganglia dysfunction. Twenty patients with s...

Full description

Saved in:
Bibliographic Details
Published in:Neuropsychologia 1998-07, Vol.36 (7), p.603-610
Main Authors: Downing, Michelle E, Phillips, James G, Bradshaw, John L, Vaddadi, Krishna S, Pantelis, Christos
Format: Article
Language:English
Subjects:
Adolescent
Adult
Adult and adolescent clinical studies
Biological and medical sciences
Female
Frontal Lobe - pathology
Functional Laterality
Humans
Kinesis
Male
Medical sciences
Motor Skills
Psychology. Psychoanalysis. Psychiatry
Psychopathology. Psychiatry
Psychoses
Schizophrenia
Schizophrenia - physiopathology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Schizophrenia may involve disturbed subcortical mechanisms or anomalous functional asymmetries. We therefore examined any anomalies of functional asymmetry in a kinematic analysis of a cued sequential movement task previously found to be sensitive to basal ganglia dysfunction. Twenty patients with schizophrenia and 20 matched controls used preferred or non-preferred hand to connect a series of targets on a WACOM SD420 graphics ,tablet, in response to the pattern of illumination of light emitting diodes (LEDs). Movements were to be initiated with or without an external cue as to target location. Patients with schizophrenia exhibited relatively normal functional asymmetries, but had programming deficits, taking longer to initiate (i.e. self generate) movements in the absence of an external cue. The movements of patients with schizophrenia were more variable and less efficient, resembling those seen in Huntington’s disease. Results supported a hypothesis of disturbance at some level in fronto-subcortical circuitry in schizophrenia.
ISSN:0028-3932
1873-3514
DOI:10.1016/S0028-3932(97)00160-7