Effect of bromazepam versus placebo on inhibition and waiting capacity in young women with traits of anxiety

Summary— The effect of 3 dosages of bromazepam administered as single oral doses (1.5, 3 and 6 mg) on anxious inhibition phenomena was studied in a population of 16 young women (18–30 years) with anxiety‐traits, selected on the criteria of Cattell's anxiety scale supported by two personality in...

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Bibliographic Details
Published in:Fundamental & clinical pharmacology 1998-01, Vol.12 (4), p.463-467
Main Authors: Schuck, S, Allain, H, Gandon, J-M, Patat, A, Millet, V, Le Coz, F
Format: Article
Language:English
Subjects:
Administration, Oral
Adolescent
Adult
Anti-Anxiety Agents - pharmacology
Anti-Anxiety Agents - therapeutic use
anxiety
Anxiety - drug therapy
Attention - drug effects
benzodiazepine
Biological and medical sciences
bromazepam
Bromazepam - pharmacology
Bromazepam - therapeutic use
cognition
Double-Blind Method
Female
Humans
inhibition
Medical sciences
memory
Memory - drug effects
Neuropharmacology
Pharmacology. Drug treatments
Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease)
Psychology. Psychoanalysis. Psychiatry
Psychometrics
Psychopharmacology
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Summary:Summary— The effect of 3 dosages of bromazepam administered as single oral doses (1.5, 3 and 6 mg) on anxious inhibition phenomena was studied in a population of 16 young women (18–30 years) with anxiety‐traits, selected on the criteria of Cattell's anxiety scale supported by two personality inventory (Eysenck's, MMPI). A double‐blind, placebo study design was chosen. The main assessment criteria were based on the go/no‐go test (Logan's procedure), slow response rate (SRR) and a task of forced or unforced decision (use of the CFF). Attentional processes and declarative memory were analyzed as secondary criteria. None of the three dosages modified inhibition or acting‐out. Sustained attention was reduced with 1.5 mg and 6 mg, as was memory performance with 3 and 6 mg, 3.5 h after drug administration. In contradistinction with studies carried out in healthy volunteers or with other benzodiazepine compounds, bromazepam at single low dosages does not modify inhibition capacity in these subjects with traits of anxiety, in this particular procedure.
ISSN:0767-3981
1472-8206
DOI:10.1111/j.1472-8206.1998.tb00973.x