Innate resistance to infection by intracellular bacterial pathogens differs in mice selected for maximal or minimal acute inflammatory response

The intensity of nonspecific immune reaction and the host resistance to facultative intracellular pathogens are found to be associated in lines of mice selected for maximal (AIRmax) or minimal (AIRmin) acute inflammatory reactivity. AIRmax are more resistant than AIRmin mice to Salmonella typhimuriu...

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Bibliographic Details
Published in:European journal of immunology 1998-09, Vol.28 (9), p.2913-2920
Main Authors: Araujo, Luiza M. M., Ribeiro, Orlando G., Siqueira, Maria, De Franco, Marcelo, Starobinas, Nancy, Massa, Solange, Cabrera, Wafa H. K., Mouton, Denise, Seman, Michel, Ibañez, Olga M.
Format: Article
Language:English
Subjects:
Acute-Phase Reaction - genetics
Acute-Phase Reaction - immunology
Alleles
Animals
Carrier Proteins - genetics
Carrier Proteins - immunology
Cation Transport Proteins
Genetic Predisposition to Disease
Immune response
Immunity, Innate - genetics
Inflammation
Listeria monocytogenes
Listeriosis - immunology
Membrane Proteins - genetics
Membrane Proteins - immunology
Mice
Nramp‐1
Polymorphism, Genetic
Salmonella Infections, Animal - immunology
Salmonella typhimurium
Species Specificity
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Summary:The intensity of nonspecific immune reaction and the host resistance to facultative intracellular pathogens are found to be associated in lines of mice selected for maximal (AIRmax) or minimal (AIRmin) acute inflammatory reactivity. AIRmax are more resistant than AIRmin mice to Salmonella typhimurium and Listeria monocytogenes infection, the differences between lines in LD50 being > 1000 and 100 times, respectively. This difference was shown to be related to the initial bacterial containment at the infectious focus, and to the control of bacterial multiplication in the spleen during the 1st week after s.  c. inoculation of the bacteria. Specific immune responses were not deeply affected by the selective process: antibody production and delayed‐type hypersensitivity were both of similar intensity in AIRmax and AIRmin mice. The differential susceptibility to infection seems independent of the Nramp‐1 locus polymorphism; therefore, these two lines represent a powerful model for investigating the role of other genetic loci regulating the nonspecific immunity effectors in the course of infectious diseases.
ISSN:0014-2980
1521-4141
DOI:10.1002/(SICI)1521-4141(199809)28:09<2913::AID-IMMU2913>3.0.CO;2-3