Apolipoprotein E allele frequencies in argyrophilic grain disease

Apolipoprotein E (ApoE) genotypes were analyzed in 35 subjects with argyrophilic grain diseases (AgD). Neuropathologically, all cases were characterized by abundant argyrophilic grains in the hippocampus and in the entorhinal or parahippocampal cortex. We found an ApoE epsilon4 allele frequency of 0...

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Bibliographic Details
Published in:Acta neuropathologica 1998-09, Vol.96 (3), p.225-227
Main Authors: TOLNAY, M, PROBST, A, MONSCH, A. U, STAEHELIN, H. B, EGENSPERGER, R
Format: Article
Language:English
Subjects:
Aged
Aged, 80 and over
Alleles
Alzheimer Disease - genetics
Alzheimer's disease
Apolipoprotein E
Apolipoprotein E2
Apolipoproteins
Apolipoproteins E - genetics
Biological and medical sciences
Brain - pathology
Brain Chemistry
Cerebellum - chemistry
Cortex (entorhinal)
Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases
Dementia - etiology
Dementia - genetics
Diagnosis, Differential
DNA - analysis
Female
Gene Frequency
Genotype
Genotypes
Humans
Kidney - chemistry
Liver - chemistry
Male
Medical sciences
Neurodegenerative diseases
Neurodegenerative Diseases - genetics
Neurology
Parahippocampal gyrus
Polymerase Chain Reaction
Population genetics
Risk Factors
Citations: Items that cite this one
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Summary:Apolipoprotein E (ApoE) genotypes were analyzed in 35 subjects with argyrophilic grain diseases (AgD). Neuropathologically, all cases were characterized by abundant argyrophilic grains in the hippocampus and in the entorhinal or parahippocampal cortex. We found an ApoE epsilon4 allele frequency of 0.007 in AgD patients, which is significantly different from the epsilon4 allele frequencies reported in age-matched Alzheimer's disease (AD) patients (0.24), but not from age-matched controls (0.09). We conclude that the ApoE epsilon4 allele does not constitute a risk factor for the development of AgD. Our results further suggest that AgD is a progressive disorder differentiated from AD by morphological and genetic criteria.
ISSN:0001-6322
1432-0533
DOI:10.1007/s004010050887