Factors defining the rate of oxygen uptake by the red blood cell

Using numerical methods, the initial rates of oxygen uptake by the red blood cell have been computed. The methods accommodate both a water layer and membrane which may act as diffusive impedance to gas influx. The differential solubilities of the gas in these two layers have also been incorporated i...

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Bibliographic Details
Published in:Bulletin of mathematical biology 1982, Vol.44 (1), p.135-147
Main Authors: Weingarden, M, Mizukami, H, Rice, S A
Format: Article
Language:English
Subjects:
erythrocytes
Erythrocytes - metabolism
Hemoglobins - metabolism
Humans
Kinetics
Models, Biological
oxygen
Oxygen Consumption
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Summary:Using numerical methods, the initial rates of oxygen uptake by the red blood cell have been computed. The methods accommodate both a water layer and membrane which may act as diffusive impedance to gas influx. The differential solubilities of the gas in these two layers have also been incorporated in the methods. Experimental studies of CO and NO uptake by the red cell could also be simulated. Although a membrane-only model with given parameters can also account for the observed rates of oxygenation of the red cell, the additional incorporation of differential solubilities of oxygen in the different layers of the RBC yields results that indicate a three layer model to be more plausible. Using a thin layer-red cell oxygenation system, the rate of oxygenation were determined for red cells surrounded by a 4.2 mu m deoxygenated water layer. The rates were found to compare favorably to the results of the theoretical model.
ISSN:0092-8240
1522-9602
DOI:10.1007/BF02459424