The possible role of acetate in exercise hyperemia in dog skeletal muscle

The possible role of acetate in the genesis of exercise hyperemia was studied in five series of dogs. Intraarterial infusion of an isomotic solution of sodium acetate at 0.76 ml/min in the dog forelimb decreased the resistance to flow through skeletal muscle by 48%, primarily by decreasing resistanc...

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Bibliographic Details
Published in:Pflügers Archiv 1982-02, Vol.392 (4), p.315-321
Main Authors: Steffen, R P, McKenzie, J E, Haddy, F J
Format: Article
Language:English
Subjects:
Acetates - blood
Acetates - pharmacology
Acetates - physiology
Acetic Acid
Anesthesia, General
Animals
Arteries
Consciousness
Dogs
Forelimb - analysis
Forelimb - blood supply
Hyperemia - physiopathology
Lymph - physiology
Muscle Proteins - physiology
Muscles - metabolism
Muscles - physiopathology
Physical Exertion
Skin - blood supply
Space life sciences
Vascular Resistance - drug effects
Veins
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Summary:The possible role of acetate in the genesis of exercise hyperemia was studied in five series of dogs. Intraarterial infusion of an isomotic solution of sodium acetate at 0.76 ml/min in the dog forelimb decreased the resistance to flow through skeletal muscle by 48%, primarily by decreasing resistance to flow through small vessels. Skin lymph flow and lymph protein concentration were unaffected. The hindlimb of the conscious dog took up acetate at rest (A-V difference, + 58.3 +/- 19.6 nmoles/ml) and put out acetate during treadmill exercise (A-V difference, -105.6 +/- 20.12 nmoles/ml); femoral venous blood acetate concentration increased by 145 nmoles/ml (control 195 nmoles/ml). In the gracilis muscle of the anesthetized dog, simulated exercise at 0.5, 1.0 or 2.0 Hz increased acetate tissue content (72, 248 and 442 nmoles/g, respectively), output (18,899, and 1,830 nmoles/100 g/min, respectively) and venous concentration (82, 49 and 39 nmoles/ml, respectively) and changes in tissue acetate content correlated with changes in vascular resistance r = 0.75, P less than 0.001. Intraarterial infusion of an isosmotic solution of sodium acetate in the quiescent gracilis muscle perfused at constant flow produced a significant (6%) decrease in resistance when arterial blood acetate was increased by a calculated 96 nmoles/ml. These studies suggest that acetate might be included among those metabolites that contribute to exercise hyperemia.U
ISSN:0031-6768
1432-2013
DOI:10.1007/BF00581625