THE TOTAL SYNTHESIS OF NOCARDICIN A

We report here a total synthesis of nocardicin A. The antibiotic was obtained as a mixture of diastereoisomers that possessed approximately one quarter of the antibacterial activity of the naturally occurring material.

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Published in:Journal of antibiotics 1982, Vol.35(3), pp.329-334
Main Authors: CURRAN, WILLIAM V., SASSIVER, MARTIN L., ROSS, ADMA S., FIELDS, THOMAS L., BOOTHE, JAMES H.
Format: Article
Language:English
Subjects:
Anti-Bacterial Agents - chemical synthesis
Anti-Bacterial Agents - pharmacology
Chemical Phenomena
Chemistry
Lactams - chemical synthesis
Lactams - pharmacology
Stereoisomerism
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container_end_page 334
container_issue 3
container_start_page 329
container_title Journal of antibiotics
container_volume 35
creator CURRAN, WILLIAM V.
SASSIVER, MARTIN L.
ROSS, ADMA S.
FIELDS, THOMAS L.
BOOTHE, JAMES H.
description We report here a total synthesis of nocardicin A. The antibiotic was obtained as a mixture of diastereoisomers that possessed approximately one quarter of the antibacterial activity of the naturally occurring material.
doi_str_mv 10.7164/antibiotics.35.329
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subjects Anti-Bacterial Agents - chemical synthesis
Anti-Bacterial Agents - pharmacology
Chemical Phenomena
Chemistry
Lactams - chemical synthesis
Lactams - pharmacology
Stereoisomerism
title THE TOTAL SYNTHESIS OF NOCARDICIN A
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