Bioavailability of Regular and Controlled-Release Chlorpheniramine Products

The bioavailability of chlorpheniramine regular-release versus controlled-release products was compared using 15 human subjects. The dosage forms evaluated were an 8-mg barrier coated-bead capsule, an 8-mg repeat action tablet, two 4-mg tablets, and 4- and 8-mg syrups. Single doses of each product w...

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Bibliographic Details
Published in:Journal of pharmaceutical sciences 1982-08, Vol.71 (8), p.919-923
Main Authors: Kotzan, J.A., Vallner, J.J., Stewart, J.T., Brown, W.J., Viswanathan, C.T., Needham, T.E., Dighe, S.V., Malinowski, R.
Format: Article
Language:English
Subjects:
Adolescent
Adult
Bioavailability-regular and controlled-celease chlorpheniramine products
Bioavailability—regular and controlled-release chlorpheniramine products
Biological Availability
Chlorpheniramine - administration & dosage
Chlorpheniramine - blood
Chlorpheniramine - metabolism
Chlorpheniramine—bioavailability of regular and controlled-release products
Controlled-release products-bioavailability of chlorpheniramine
Delayed-Action Preparations
Humans
Keyphrases D Chlorpheniramine-bioavailability of regular and controlled-release products
Kinetics
Male
Therapeutic Equivalency
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Summary:The bioavailability of chlorpheniramine regular-release versus controlled-release products was compared using 15 human subjects. The dosage forms evaluated were an 8-mg barrier coated-bead capsule, an 8-mg repeat action tablet, two 4-mg tablets, and 4- and 8-mg syrups. Single doses of each product were administered orally in a 5-way crossover study, plasma samples were collected at specific time intervals, and chlorpheniramine levels assayed by HPLC. Pharmacokinetic analysis was based on a two-compartment open model. The average plasma elimination half-life of chlorpheniramine was calculated to be ~18.3 hr. The controlled-release products gave a higher Cmax than the 4-mg syrup, but
ISSN:0022-3549
1520-6017
DOI:10.1002/jps.2600710820