High-density lipoprotein subfractions in normolipidemic patients with coronary atherosclerosis

High-density lipoprotein (HDL) levels were studied in 10 male patients with severe coronary atherosclerosis and in 10 well-matched controls. All subjects were normolipidemic, and the presence of a disease or other factor influencing HDL levels were excluded. Very low density lipoprotein and low-dens...

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Bibliographic Details
Published in:Circulation (New York, N.Y.) N.Y.), 1982-11, Vol.66 (5), p.923-926
Main Authors: Brook, J G, Aviram, M, Viener, A, Shilansky, E, Markiewicz, W
Format: Article
Language:English
Subjects:
Adult
Aged
Coronary Disease - blood
Humans
Lipoproteins, HDL - blood
Lipoproteins, HDL2
Lipoproteins, HDL3
Lipoproteins, LDL - blood
Lipoproteins, VLDL - blood
Male
Middle Aged
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Summary:High-density lipoprotein (HDL) levels were studied in 10 male patients with severe coronary atherosclerosis and in 10 well-matched controls. All subjects were normolipidemic, and the presence of a disease or other factor influencing HDL levels were excluded. Very low density lipoprotein and low-density lipoprotein levels were similar in both groups, but HDL concentration was significantly lower in the patient group. Analysis of HDL subfractions revealed that both HDL2 and HDL3 concentrations were significantly lower in the patient group. The composition of both HDL subfractions was also altered in the patient group: an increased cholesterol-to-protein ratio was found. These data strengthen the evidence in support of an important and independent role for HDL in the pathogenesis of coronary atherosclerosis. It appears that both HDL2 and HDL3 are implicated and that both the concentration and composition of HDL are important.
ISSN:0009-7322
1524-4539
DOI:10.1161/01.CIR.66.5.923