Biomolecular Characterization and Protein Sequences of the Campanian Hadrosaur B. canadensis

Molecular preservation in non-avian dinosaurs is controversial. We present multiple lines of evidence that endogenous proteinaceous material is preserved in bone fragments and soft tissues from an 80-million-year-old Campanian hadrosaur, Brachylophosaurus canadensis [Museum of the Rockies (MOR) 2598...

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Bibliographic Details
Published in:Science (American Association for the Advancement of Science) 2009-05, Vol.324 (5927), p.626-631
Main Authors: Schweitzer, Mary H., Zheng, Wenxia, Organ, Chris L., Avci, Recep, Suo, Zhiyong, Freimark, Lisa M., Lebleu, Valerie S., Duncan, Michael B., Heiden, Matthew G. Vander, Neveu, John M., Lane, William S., Cottrell, John S., Horner, John R., Cantley, Lewis C., Kalluri, Raghu, Asara, John M.
Format: Article
Language:English
Subjects:
Amino Acid Sequence
Animals
Antibodies
Birds - classification
Blood vessels
Bone Demineralization Technique
Bone Matrix - chemistry
Bones
Collagen - analysis
Collagen - chemistry
Collagen - isolation & purification
Collagens
Dinosaurs
Dinosaurs - classification
Earth sciences
Earth, ocean, space
Elastin - analysis
Exact sciences and technology
Femur - blood supply
Femur - chemistry
Femur - ultrastructure
Fossils
Hemoglobins - analysis
Immunologic Techniques
Laminin - analysis
Mass Spectrometry
Mass spectroscopy
Microscopy, Electron, Scanning
Molecular biology
Molecular Sequence Data
Osteocytes
Osteocytes - ultrastructure
Ostriches
Paleontology
Peptide Fragments - chemistry
Peptide Fragments - isolation & purification
Phylogeny
Prehistoric era
Proteins
Proteins - analysis
Proteins - chemistry
Proteins - isolation & purification
Sediments
Sequence Alignment
Tissues
Vertebrate paleontology
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Description
Summary:Molecular preservation in non-avian dinosaurs is controversial. We present multiple lines of evidence that endogenous proteinaceous material is preserved in bone fragments and soft tissues from an 80-million-year-old Campanian hadrosaur, Brachylophosaurus canadensis [Museum of the Rockies (MOR) 2598]. Microstructural and immunological data are consistent with preservation of multiple bone matrix and vessel proteins, and phylogenetic analyses of Brachylophosaurus collagen sequenced by mass spectrometry robustly support the bird-dinosaur clade, consistent with an endogenous source for these collagen peptides. These data complement earlier results from Tyrannosaurus rex (MOR 1125) and confirm that molecular preservation in Cretaceous dinosaurs is not a unique event.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.1165069